229306-11-0

Basic information

• Product Name: (1R,2S,3R,4S,5R)-4-acetamido-1-O-acetyl-2-O-phenoxythiocarbonyl-3-O-phenylcarbamoyl-1,2,3-cyclopentanetriol
• Synonyms: (1R,2S,3R,4S,5R)-4-acetamido-1-O-acetyl-2-O-phenoxythiocarbonyl-3-O-phenylcarbamoyl-1,2,3-cyclopentanetriol
• CAS NO: 229306-11-0
• Molecular Weight: 518.612
• Mol File: 229306-11-0.mol

Chemical Properties

• CAS DataBase Reference: (1R,2S,3R,4S,5R)-4-acetamido-1-O-acetyl-2-O-phenoxythiocarbonyl-3-O-phenylcarbamoyl-1,2,3-cyclopentanetriol(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,2S,3R,4S,5R)-4-acetamido-1-O-acetyl-2-O-phenoxythiocarbonyl-3-O-phenylcarbamoyl-1,2,3-cyclopentanetriol(229306-11-0)
• EPA Substance Registry System: (1R,2S,3R,4S,5R)-4-acetamido-1-O-acetyl-2-O-phenoxythiocarbonyl-3-O-phenylcarbamoyl-1,2,3-cyclopentanetriol(229306-11-0)

Safety Data

• Hazardous Substances Data: 229306-11-0(Hazardous Substances Data)

Upstream product

• 1005-56-7 phenylcarbonochloridothioate 
• 229306-09-6 (1R,2S,3R,4S,5R)-4-acetamido-1-O-acetyl-3-O-phenylcarbamoyl-1,2,3-cyclopentanetriol 
• 229306-08-5 Phenyl-carbamic acid (3aR,4R,5S,6R,6aR)-5-acetylamino-2-methoxy-2-methyl-6-methylsulfanyl-tetrahydro-cyclopenta[1,3]dioxol-4-yl ester 
• 103-71-9 phenyl isocyanate 
• 171032-10-3 1,2-O-cyclohexylidene 1D-(1,2,3,4/5)-4-acetamido-5-(methylthio)-1,2,3-cyclopentanetriol 
• 229306-07-4 1,2-O-cyclohexylidene (1R,2S,3R,4S,5R)-4-acetamido-3-O-phenylcarbamoyl-5-methylthio-1,2,3-cyclopentanetriol 

Downstream Products

• 229306-13-2 (1S,2S,3R,4R)-2-acetamido-4-O-acetyl-3-methylthio-1-O-phenoxythiocarbonyl-1,4-cyclopentanediol 

Relevant articles and documents

Synthesis and α-mannosidase inhibitory activity of three deoxy derivatives of mannostatin A

Three deoxy derivatives 2-4 of the α-mannosidase inhibitor mannostatin A (1) were synthesized, and their inhibition of Jack bean α-mannosidase was evaluated in order to elucidate the roles of each of the three hydroxyl groups of the inhibitor. The 1- and 2-deoxy derivatives 2 and 3 retained some inhibitory activity, although reduced by a factor of about 100 relative to the parent, whereas it was completely lost with the 3-deoxy derivative 4. Structure and activity relationships are discussed in the light of these findings.

Synthesis and biological evaluation of α-mannosidase inhibitory activity of three deoxy derivatives of mannostatin A

Three deoxy derivatives of α-mannosidase inhibitor mannostatin A have been synthesized and their inhibitory activity for Jack beans α-mannosidase evaluated in order to elucidate roles of each hydroxyl groups of the inhibitor. The 1- and 2-deoxy derivatives have preserved inhibitory potentials although they lowered the activity one-hundred fold compared to the parent, but the 3-deoxy derivative lost activity.