229308-47-8

Upstream product

• 229308-50-3 N-chloro-3-methyl-4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridin-4-one 
• 1227368-46-8 C₁₄H₂₂N₂O₅ 
• 229308-48-9 3-(2-benzyloxycarbonylaminoethyl)isoxazole-4-carboxylate 

Downstream Products

• 1227368-53-7 7-(4-hydroxyphenyl)-3-methyl-4,5-dihydroisoxazolo[4,3-c]pyridin-4-one 
• 1375104-22-5 3-[2-(4-bromophenyl)ethenyl]-4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridin-4-one 
• 1375104-27-0 3-[2-hydroxy-2-(4-bromophenyl)ethyl]-4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridin-4-one 
• 1375104-23-6 3-[2-(2,4-dichlorophenyl)ethenyl]-4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridin-4-one 
• 1375104-28-1 3-[2-hydroxy-2-(2,4-dichlorophenyl)ethyl]-4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridin-4-one 
• 1375104-20-3 3-(2-phenylethenyl)-4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridin-4-one 
• 1375104-26-9 3-(2-hydroxy-2-phenylethyl)-4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridin-4-one 
• 1375104-21-4 3-[2-(4-nitrophenyl)ethenyl]-4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridin-4-one 
• 1375104-32-7 3-[2-(2-hexa-3,5-dienylphenyl)-2-hydroxyethyl]-4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridin-4-one 
• 229308-55-8 3-acetyl-4-amino-1H-pyridin-2-one 
• 229308-51-4 3-methyl-4,5-dihydroisoxazolo[4,3-c]pyridin-4-one 
• 226704-37-6 3-(1-Hydroxyethylidene)piperidine-2,4-dione 
• 106727-54-2 3-Acetyl-1,2-dihydro-4-hydroxypyridin-2-one 

Relevant academic research and scientific papers

Dehydrogenation-halogenation of a 4,5,6,7-tetrahydroisoxazolo[4,3-c] pyridin-4-one to provide a scaffold for acylpyridones

The dehydrogenation and halogenation of 3-methyl-4,5,6,7- tetrahydroisoxazolo[4,3-c]pyridin-4-one has been investigated to provide a suitable 7-halo-4,5-dihydroisoxazolo[4,3-c]pyridine-4-one to act as a masked scaffold for the acylpyridone natural products and analogues. ARKAT-USA, Inc.

New methodologies for the synthesis of 3-acylpyridone metabolites

A core isoxazolo[4,3-c]pyridin-4-one scaffold is prepared and elaborated at C-3(Me) and C-7 as a masked building block for 3-acylpyridin-2-ones related to the acylpyridone natural products Georg Thieme Verlag Stuttgart.

A second-generation cycloaddition approach to 3-acyl-4-hydroxypyridin- 2-ones

The 1,3-dipolar cycloaddition of the β-aminonitrile oxide, formed from β-alanine, to the enamine of a β-ketoester affords a 3-(2- aminoalkyl)isoxazole-4-carboxylic ester that is converted via isoxazolo[4,5- c]pyridin-4-ones into 3-acetyl-4-hydroxypyridin-2-ones.