229323-98-2Relevant academic research and scientific papers
Synthesis and antimalarial activity of novel medium-sized 1,2,4,5-tetraoxacycloalkanes
Kim,Nagai,Ono,Begum,Wataya,Hamada,Tsuchiya,Masuyama,Nojima,McCullough
, p. 2357 - 2361 (2007/10/03)
CsOH- or Ag2O-mediated cycloalkylation of (alkylidene)bisperoxides 3 and 1,n-dihaloalkanes (n = 3-8) provided the corresponding medium-sized 1,2,4,5-tetraoxacycloalkanes 4-8 in moderate yields. Subsequent evaluation of the antimalarial activity of the cyclic peroxides 4-8 in vitro and in vivo revealed that 1,2,6,7-tetraoxaspiro[7.11]nonadecane 4a has considerable potential as a new, inexpensive, and potent antimalarial drug.
Synthesis, crystal structure and anti-malarial activity of novel spiro- 1,2,4,5-tetraoxacycloalkanes
Tsuchiya, Kaoru,Hamada, Yoshiaki,Masuyama, Araki,Nojima, Masatomo,McCullough, Kevin J.,Kim, Hye-Sook,Shibata, Yasuharu,Wataya, Yusuke
, p. 4077 - 4080 (2007/10/03)
(Cycloalkylidene)bishydroperoxides 3 react with 1,n-dihaloalkanes (n = 3-6) in the presence of CsOH-H2O in DMF affording the corresponding spiro- 1,2,4,5-tetraoxacycloalkanes 4 in moderate yields. Compound 4ba exhibits significant antimalarial activity in vitro against P. falciparum.
