2294-47-5Relevant articles and documents
Synthesis, molecular docking, and evaluation of novel bivalent pyrazolinyl-1,2,3-triazoles as potential VEGFR TK inhibitors and anti-cancer agents
Abd-Rabou, Ahmed A.,Abdel-Wahab, Bakr F.,Bekheit, Mohamed S.
, p. 2225 - 2237 (2018)
Abstract: Investigations in the discovery of tyrosinase enzyme inhibitors have the potential to design novel anti-cancer drugs. A variety of novel bivalent pyrazolinyl triazoles 5–7 were synthesized and identified. The bis-acetyl triazole 3 was accomplish
New cyclic RGD peptides: Synthesis, characterization, and theoretical activity towards αvβ3 integrin
Vila?a, Helena,Ferreira, Paula M.T.,Micaelo, Nuno M.
, p. 5420 - 5427 (2014)
Two new cyclic RGD peptides were prepared using a click chemistry approach. The linear RGDfV peptide was synthesized by solid-phase peptide synthesis using a 9-fluorenylmetoxicarbonyl (Fmoc) strategy and a 2-chlorotrityl chloride resin. After coupling 5-h
Bis-ethynylphosphonamidates as an Modular Conjugation Platform to Generate Multi-Functional Protein- and Antibody-Drug-Conjugates
Hackenberger, Christian P. R.,Helma, Jonas,Kasper, Marc-André,Lassak, Lukas,Mai, Isabelle,Schumacher, Dominik,Vogl, Annette M.
supporting information, (2022/01/20)
Bis-ethynylphosphonamidates allow for a simple chemoselective addition of two thiol-containing modules in a row. We describe four such bis-electrophiles that carry different functional O-substituents with tunable hydrophilicity and enable further subseque
Linear C2 symmetric compound, lanthanide polynuclear complex and preparation method and application of lanthanide polynuclear complex
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Paragraph 0112; 0121-0122, (2020/08/18)
The invention discloses a linear C2 symmetric compound, a lanthanide polynuclear complex and a preparation method and application of the lanthanide polynuclear complex, and belongs to the field of photochemical supramolecules. The structural formula of the linear C2 symmetric compound is shown in the specification. The linear C2 symmetric compound is obtained by carrying out triazole cyclization reaction on an azide compound and an alkyne compound at the temperature of 50-70 DEG C. The lanthanide polynuclear complex has a general formula Ln2nL3n, wherein Ln is selected from lanthanide, L is anorganic ligand selected from the linear C2 symmetric compound, and n is selected from 1 or 2. The preparation method comprises the steps: carrying out a reaction on a lanthanide Ln precursor with theorganic ligand L at the temperature of 30-50 DEG C. The linear C2 symmetric compound comprises a triazole-pyridine-amide chelating group, can improve the efficiency of energy transfer from an intermediate chromophore of the ligand to a rare earth center, and improve the construction of a lanthanide complex having a high nuclear number, and thus the obtained complex having strong light-emitting properties and includes a lanthanide organic polyhedral cage having a high nuclear number.