22944-10-1Relevant academic research and scientific papers
Total synthesis of Sparstolonin B, a potent anti-inflammatory agent
Wang, Yongqiang,Wang, Chao,Wang, Yuanxun,Dong, Lijin,Sun, Jian
, p. 12354 - 12357 (2015/02/19)
Two concise routes for the first total synthesis of Sparstolonin B (SsnB) have been described. The synthesis of SsnB could be accomplished in 5 and 6 steps with 40% and 38% overall yield, respectively. The rhodium-catalysed oxidative coupling of benzoic a
Electrophilic cyclization of 2-chalcogenealkynylanisoles: Versatile access to 2-chalcogen-benzo[b]furans
Manarin, Flavia,Roehrs, Juliano A.,Gay, Rafaela Mozzaquatro,Brandao, Ricardo,Menezes, Paulo H.,Nogueira, Cristina W.,Zeni, Gilson
body text, p. 2153 - 2162 (2009/07/01)
An efficient synthesis of 2-ehalcogen-3-substituted-benzo[b]furan compounds has been accomplished via electrophilic cyclization reaction of 2-chalcogenealkynyl anisoles using I2, ICl, Br2, and PhSeBr as electrophile sources. The product distributions were strongly dependent on the nature of substituents in the aromatic ring of anisole and on the chalcogen atom directly bonded to the triple bond. The 2-chalcogen-3-iodo- benzo[b]furans obtained smoothly underwent conversion to more complex structures of benzo-[b]furan derivatives via palladium- or copper-catalyzed cross-coupling reaction with thiols, diphenyl diselenides, and zincates.
Preparation and characterisation of a quinone-functionalised polythiophene film on a modified electrode. Application to the potentiometric determination of glutathione and cysteine concentrations
étienne, Stéphanie,Matt, Muriel,Oster, Thierry,Samadi, Mohammad,Beley, Marc
, p. 9619 - 9624 (2008/12/22)
The new compound 3-((2,5-dimethoxyphenyl)ethynyl)thiophene has been synthesised by Sonogashira coupling. A modified electrode coated with a polythiophene film bearing a quinone moiety was obtained by electropolymerisation of the thienyl group followed by anodic oxidation of para-dimethoxyphenyl group. The cyclovoltammetric response resulting from the reaction of glutathione with the benzoquinone moiety was investigated. The responses of the modified electrode as a new potentiometric sensor of reduced thiols are proposed.
A practical synthesis of 6-[2-(2,5-dimethoxyphenyl)ethyl]-4-ethylquinazoline and the art of removing palladium from the products of Pd-catalyzed reactions
Koenigsberger, Kurt,Chen, Guang-Pei,Wu, Raeann R.,Girgis, Michael J.,Prasad, Kapa,Repic, Oljan,Blacklock, Thomas J.
, p. 733 - 742 (2013/09/05)
A concise large-scale synthesis of 1, a new antimitotic agent is described. The key step was a one-pot Sonogashira cross-coupling of an aryl halide with a heteroaryl halide through an acetylene using the readily available 2-methyl-3-butyn-2-ol (7). An innovative approach for palladium removal was designed and successfully scaled-up on a multikilogram scale. The product was crystallized from the crude reaction mixture while keeping the residual palladium in the mother liquor by using Pd-scavenging agents such as N-acetylcysteine or thiourea.
