229478-44-8Relevant academic research and scientific papers
Factors influencing agonist potency and selectivity for the opioid δ receptor are revealed in structure - Activity relationship studies of the 4-[(n-substituted-4-piperidinyl)arylamino]-n,n-diethylbenzamides
Thomas,Herault,Rothman,Atkinson,Burgess,Mascarella,Dersch,Xu,Flippen-Anderson,George,Carroll
, p. 972 - 987 (2001)
A study of the effect of transposition of the internal nitrogen atom for the adjacent benzylic carbon atom in δ-selective agonists such as BW373U86 (1) and SNC-80 (2) has been undertaken. It was shown that high-affinity, fully efficacious, and δ opioid re
(+/-)-4-[(N-allyl-cis-3-methyl-4-piperidinyl)phenylamino]-N,N-diethylbenzamide displays selective binding for the delta opioid receptor.
Thomas,Herault,Rothman,Burgess,Mascarella,Xu,Horel,Dersch,Carroll
, p. 3053 - 3056 (1999)
Racemic 4-[(N-allyl-cis-3-methyl-4-piperidinyl)phenylamino]-N,N-diethylbenzam ide (3a) was synthesized and found to have good affinity and selectivity for the delta receptor. These compounds can be viewed as an analog of BW373U86 and SNC-80 where an inter
