229479-52-1

Usage

Classification

Piperidine derivative

Usage

Research chemical

Receptor interaction

Potent and selective μ-opioid receptor agonist

Effects

Binds to and activates μ-opioid receptors in the central nervous system, leading to physiological and psychoactive effects

Legal status

Controlled substance in many countries

Research focus

Study of opioid receptors, pain management, and addiction

Medical applications

Limited scientific research on potential therapeutic uses

Availability

Not widely available due to legal restrictions and limited research

Upstream product

• 3612-18-8 N-ethyl-4-piperidone 
• 62-53-3 aniline 

Relevant academic research and scientific papers

Dissection of N,N-diethyl-N′-phenylpiperazines as α7 nicotinic receptor silent agonists This manuscript is dedicated to Professor Koji Nakanishi on the occasion of his 90th birthday

The α7 nicotinic acetylcholine receptor (nAChR) is a target for control of inflammation-related phenomena via compounds that are able to selectively induce desensitized states of the receptor. Compounds that selectively desensitize, without facilitating s

NICOTINIC ACETYLCHOLINE RECEPTOR SILENT AGONISTS

Derivatives of N,N-diethyl-N'- phenyl-piperazine, a silent agonist of the mammalian α7 nicotinic acetylcholine receptor, are provided. These silent agonists control the desensitization state of the receptor. Further provided are pharmaceutical compositions that allow the administration of the silent agonists of the disclosure to a subject animal or human in need of treatment for a pathological condition arising from such as inflammation. The novel silent agonists also may be co-administered to a patient simultaneously or consecutively with a type II positive allosteric modulator to modulate the activity of the receptor.

4- ARYL(PIPERIDIN-4-YL)] AMINOBENZAMIDES WHICH BIND TO THE DELTA-OPIOID RECEPTOR

4-[aryl(piperidin-4-yl)] aminobenzamides are delta-opioid receptor agonists/antagonists of formula (I). As delta-opioid receptor agonists, such compounds are useful as analgesics. Depending on their agonist/antagonist effect, such compounds may also be useful immunosuppressants, antiinflammatory agents, agents for the treatment of mental illness, medicaments for drug and alcohol abuse, agents for treating gastritis and diarrhea, cardiovascular agents, and agents for the treatment of respiratory diseases. In formula (I), [Ar is phenyl, 1-naphthyl or 2-naphthyl, each optionally substituted with 1 to 3 R; R - R are described in the application].