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4-Chloro-3-sulfamoyl-N-(4-sulfamoyl-phenyl)-benzamide is a complex organic compound with the molecular formula C13H10ClN3O4S2. It is characterized by the presence of a benzamide core, with a 4-chloro substitution on the benzene ring, and a sulfamoyl group attached to both the 3rd position of the benzamide and the 4th position of the phenyl group. 4-Chloro-3-sulfamoyl-N-(4-sulfamoyl-phenyl)-benzamide is known for its potential applications in pharmaceutical research, particularly in the development of drugs targeting various diseases. Its chemical structure provides a foundation for understanding its interactions with biological targets, such as enzymes or receptors, which can be crucial for its therapeutic effects. The compound's unique combination of functional groups, including the chloro, sulfamoyl, and amide moieties, contributes to its specific chemical properties and potential pharmacological activities.

2295-64-9

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2295-64-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 2295-64-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,2,9 and 5 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 2295-64:
(6*2)+(5*2)+(4*9)+(3*5)+(2*6)+(1*4)=89
89 % 10 = 9
So 2295-64-9 is a valid CAS Registry Number.

2295-64-9Downstream Products

2295-64-9Relevant academic research and scientific papers

Carbonic anhydrase inhibitors: 4-Sulfamoyl-benzenecarboxamides and 4-chloro-3-sulfamoyl-benzenecarboxamides with strong topical antiglaucoma properties

Mincione, Francesco,Starnotti, Michele,Menabuoni, Luca,Scozzafava, Andrea,Casini, Angela,Supuran, Claudiu T.

, p. 1787 - 1791 (2001)

Reaction of 4-carboxy-benzenesulfonamide or 4-chloro-3-sulfamoyl benzoic acid with carboxy-protected amino acids/dipeptides, or aromatic/heterocyclic sulfonamides/mercaptans afforded the corresponding benzene-carboxamide derivatives. These were tested as inhibitors of three carbonic anhydrase (CA) isozymes, CA I, II and IV. Some of the new derivatives showed affinity in the low nanomolar range for isozymes CA II and IV, involved in aqueous humor secretion within the eye, and were tested as topically acting anti-glaucoma agents, in normotensive and glaucomatoous rabbits. Good in vivo activity and prolonged duration of action has been observed for some of these derivatives, as compared to the clinically used drugs dorzolamide and brinzolamide. Some of the 4-chloro-3-sulfamoyl benzenecarboxamides reported here showed higher affinity for CA I than for the sulfonamide avid isozyme CA II.

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