22956-02-1

Upstream product

• 99430-03-2 2'-hydroxy-5'-methoxychalcone 
• 588-72-7 [(E)-2-bromoethenyl]benzene 
• 351981-21-0 C₁₅H₁₆N₂O₄S 
• 672-13-9 2-hydroxy-5-methoxybenzaldehyde 
• 103-64-0 bromostyrene 
• 150-76-5 4-methoxy-phenol 
• 4187-87-5 1-Phenyl-2-propyn-1-ol 
• 121507-53-7 1-Methoxy-4-(1-phenyl-prop-2-ynyloxy)-benzene 

Relevant academic research and scientific papers

Kinetic Resolution and Dynamic Kinetic Resolution of Chromene by Rhodium-Catalyzed Asymmetric Hydroarylation

A highly efficient kinetic resolution and dynamic kinetic resolution of chromene is reported for the first time and they procced by a rhodium-catalyzed asymmetric hydroarylation pathway. This new approach offers versatile access to various chiral 2,3-diaryl-chromanes containing vicinal stereogenic centers, as well as the recovered chiral flavenes, in high yields with excellent ee values (s factor up to 532). Particularly noteworthy is that this strategy can be further extended to the establishment of a dynamic version of the kinetic resolution of chromene acetals and allows complete access to chiral isoflavanes and α-aryl hydrocoumarins.

Solid phase synthesis method of 2H-benzopyran compounds

The invention discloses a solid phase synthesis method of 2H-benzopyron compounds (I), and belongs to the field of organic chemistry. The method comprises the following steps: (1) taking crosslinked polystyrene resin (1%) as the carrier to prepare a selen

2H-chromenes generated by an iron(III) complex-catalyzed allylic cyclization

A straightforward method based on an iron(III) complex-catalyzed cyclization of 2-(1-hydroxyallyl)phenols is reported to access a large variety of 2H-chromenes. This method was applied to the total synthesis of a natural product, tephrowatsin B.

Palladium-catalyzed coupling of N-tosylhydrazones and β-bromostyrene derivatives: New approach to 2H-chromenes

2H-Chromene is an important structural motif that exists in natural products and non-natural compounds possessing interesting biological activities. In this investigation, a highly efficient approach toward 2H-chromenes has been developed based on palladium-catalyzed coupling of N-tosylhydrazones and β-bromostyrenes. The mechanism of this reaction is proposed that involves the formation of vinyl palladium by carbene migratory insertion and the intramolecular nucleophilic substitution. This journal is

Synthesis and antiplasmodial evaluation of novel chromeno[2,3-b]chromene derivatives

5-Methoxyflavenes and 6-methoxyflavenes were found to undergo stereoselective acid-catalyzed rearrangement to generate a range of novel chromeno[2,3-b]chromene derivatives. When subjected to an in vitro antiplasmodial growth inhibition assay using Plasmod

An efficient synthesis of novel tetrahydrochromeno[2,3-b]chromenes

A series of novel tetrahydrochromeno[2,3-b]chromenes is synthesized via the acid-catalyzed dimerization reactions of 5-methoxy- or 6-methoxyflavenes. A rational mechanism for the observed rearrangement is proposed.

A NOVEL SYNTHESIS OF FLAV-3-ENES BY CLAISEN REARRANGEMENT

1-Arylprop-2-ynyl aryl ethers (6) undergo a facile Claisen rearrangement in N,N-diethylaniline/o-dichlorobenzene to give flav-3-enes in good yields.