22963-07-1

Basic information

• Product Name: 4-benzyl-2-phenyl-1,3-thiazol-5(4H)-one
• Synonyms: 4-Benzyl-2-phenyl-1,3-thiazol-5(4H)-one; 5(4H)-thiazolone, 2-phenyl-4-(phenylmethyl)-
• CAS NO: 22963-07-1
• Molecular Formula: C₁₆H₁₃NOS
• Molecular Weight: 267.3455
• Mol File: 22963-07-1.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 416.8°C at 760 mmHg
• Flash Point: 205.8°C
• Density: 1.2g/cm³
• Vapor Pressure: 3.73E-07mmHg at 25°C
• Refractive Index: 1.646
• CAS DataBase Reference: 4-benzyl-2-phenyl-1,3-thiazol-5(4H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-benzyl-2-phenyl-1,3-thiazol-5(4H)-one(22963-07-1)
• EPA Substance Registry System: 4-benzyl-2-phenyl-1,3-thiazol-5(4H)-one(22963-07-1)

Safety Data

• Hazardous Substances Data: 22963-07-1(Hazardous Substances Data)

Upstream product

• 407-25-0 trifluoroacetic anhydride 
• 51353-88-9 N-thiobenzoyl-phenylalanine amide 

Downstream Products

• 112156-87-3 4,4'-Dimethyl-2,2'-diphenyl-4H,4'H-[4,4']bithiazolyl-5,5'-dione 
• 199447-37-5 4,4'-Dibenzyl-2,2'-diphenyl-4H,4'H-[4,4']bithiazolyl-5,5'-dione 

Relevant articles and documents

Dakin-west reaction of n-thioacylprolines using trifluoroacetic anhydride: Novel access to 5-trifluoromethylthiazoles

The reaction between N-thioacylprolines and trifluoroacetic anhydride in the presence of pyridine afforded a good yield of 5-trifluoromethylthiazoles. This reaction proceeded through mesoionic 1,3-thiazolium-5-olates, followed by cleavage of the pyrrolidine ring and the formation of thiazoles, introducing a trifluoromethyl group at position 5 in the thiazole ring.