22963-07-1Relevant academic research and scientific papers
Dakin-west reaction of n-thioacylprolines using trifluoroacetic anhydride: Novel access to 5-trifluoromethylthiazoles
Hagimoto, Yuri,Saijo, Ryosuke,Kawase, Masami
, p. 709 - 724 (2014/04/03)
The reaction between N-thioacylprolines and trifluoroacetic anhydride in the presence of pyridine afforded a good yield of 5-trifluoromethylthiazoles. This reaction proceeded through mesoionic 1,3-thiazolium-5-olates, followed by cleavage of the pyrrolidine ring and the formation of thiazoles, introducing a trifluoromethyl group at position 5 in the thiazole ring.
On the tautomerism of 2,4-disubstituted thiazolones
Lin, Yuhui,Andersen, Kenneth K.
, p. 557 - 563 (2007/10/03)
Four series of thiazolones - 2-phenyl-, 2-ethyl, 2-ethoxy, and 2-(ethylthio)thiazol-5-ones - have been synthesized. The tautomeric behavior of these thiazolones is discussed, and the keto form II, i.e. 2-ethylthiazol-5(2H)one has been characterized by IR, 1H and 11C NMR spectroscopic methods for the first time.
