229643-04-3

Basic information

• Product Name: 5-chloro-1-methyl-2-(4-methoxyphenyl)imidazole
• Synonyms: 5-chloro-1-methyl-2-(4-methoxyphenyl)imidazole
• CAS NO: 229643-04-3
• Molecular Weight: 222.674
• Mol File: 229643-04-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-chloro-1-methyl-2-(4-methoxyphenyl)imidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-chloro-1-methyl-2-(4-methoxyphenyl)imidazole(229643-04-3)
• EPA Substance Registry System: 5-chloro-1-methyl-2-(4-methoxyphenyl)imidazole(229643-04-3)

Safety Data

• Hazardous Substances Data: 229643-04-3(Hazardous Substances Data)

Upstream product

• 872-49-1 N-methyl-5-chloroimidazole 
• 104-92-7 1-bromo-4-methoxy-benzene 

Relevant articles and documents

Modulating reactivity and diverting selectivity in palladium-catalyzed heteroaromatic direct arylation through the use of a chloride activating/blocking group

(Chemical Equation Presented) Through the introduction of an aryl chloride substituent, the selectivity of palladium-catalyzed direct arylation may be diverted to provide alternative regioisomeric products in high yields. In cases where low reactivity is typically observed, the presence of the carbon-chlorine bond can serve to enhance reactivity and provide superior outcomes. From a strategic perspective, the C-Cl bond is easily introduced and can be employed in a variety of subsequent transformations to provide a wealth of highly functionalized heterocycles with minimal substrate preactivation. The impact of the C-Cl functional group on direct arylation reactivity has also been evaluated mechanistically, and the observed reactivity profiles correlate very well with that predicted by a concerted metalation-deprotonation pathway.