2297-06-5

Usage

Uses

Used in Pharmaceutical Industry:
Methyl 4-amino-2-sulfamoylbenzoate is used as an intermediate in the synthesis of pharmaceuticals for its antimicrobial properties, playing a key role in the development of new antibiotics targeting a range of bacterial infections.
Used in Drug Development:
It is utilized as a compound in drug development due to its ability to inhibit the growth of certain pathogenic bacteria, thereby contributing to the creation of novel treatments for bacterial diseases.
Used in Organic Compounds Synthesis:
Methyl 4-amino-2-sulfamoylbenzoate is also used in the synthesis of dyes, pigments, and other organic compounds, highlighting its versatility beyond the pharmaceutical sector.

Upstream product

• 22952-24-5 6-nitrosaccharin 
• 2297-01-0 methyl 2-sulfonamido-4-nitrobenzoate 
• 99-55-8 2-methyl-5-nitroaniline 
• 121-02-8 2-methyl-5-nitrobenzene-1-sulfonyl chloride 
• 6269-91-6 4-nitrotoluene-2-sulfonamide 

Relevant academic research and scientific papers

Synthesis of saccharin-glycoconjugates targeting carbonic anhydrase using a one-pot cyclization/deprotection strategy

Carbonic anhydrase IX (CA IX) has been identified as a biomarker and drug target for several malignant tumors due to its role in cancer cell growth and proliferation. Simple cyclic sulfonamides, like saccharin (SAC), have shown up to a 60-fold selectivity towards CA IX over other ubiquitous CA isoforms, with greater selectivity obtained applying the “tail-approach” to derivatize SAC with a methylene triazole linker that connected to a “tail” beta glucoside. These modifications of SAC led to an increased selectivity of more than 1000-fold towards CA IX, whereas clinically available CA inhibitors show little to no isoform selectivity. As part of our interest in the development of new CA inhibitors, we found the existing synthetic protocol, which relies on a N-tert-butyl saccharin intermediate, to be problematic in the final deprotection steps. We therefore describe an alternative approach to the synthesis of these compounds featuring a gentle “one pot” deprotection/cyclization as the final synthetic step, and report new galactosyl and glucosyl conjugates with low to mid nM inhibition of CA IX.

Research on Controllable Degradation of Novel Sulfonylurea Herbicides in Acidic and Alkaline Soils

The degradation issue of sulfonylurea (SU) has become one of the biggest challenges that hamper the development and application of this class of herbicides, especially in the alkaline soils of northern China. On the basis of the previous discovery that some substituents on the fifth position of the benzene ring in Chlorsulfuron could hasten its degradation rate, apparently in acidic soil, this work on Metsulfuron-methyl showed more convincing results. Two novel compounds (I-1 and I-2) were designed and synthesized, and they still retained potent herbicidal activity in tests against both dicotyledons and monocotyledons. The half-lives of degradation (DT50) assay revealed that I-1 showed an accelerated degradation rate in acidic soil (pH 5.59). Moreover, we delighted to find that the degradation rate of I-1 was 9-10-fold faster than that of Metsulfuron-methyl and Chlorsulfuron when in alkaline soil (pH 8.46), which has more practical value. This research suggests that a modified structure that has potent herbicidal activity as well as accelerated degradation rate could be realized and this approach may provide a way to improve the residue problem of SUs in farmlands with alkaline soil.