2297-64-5

Basic information

• Product Name: 4-BROMOBENZENESULFONOHYDRAZIDE
• Synonyms: p-Bromobenzenesulfonic acid hydrazide;p-Bromobenzenesulfonic hydrazide;p-Bromobenzenesulfonylhydrazide;p-Bromophenylsulfonylhydrazine;4-BROMOBENZENESULFONIC HYDRAZIDE;Benzenesulfonic acid, 4-bromo-, hydrazide;Benzenesulfonic acid, p-bromo-, hydrazide;Benzenesulfonic acid, p-bromo-, hydrazide (8CI)
• CAS NO: 2297-64-5
• Molecular Formula: C₆H₇BrN₂O₂S
• Molecular Weight: 251.11
• Mol File: 2297-64-5.mol
• Article Data: 58

Chemical Properties

• Melting Point: 118 °C (decomp)
• Boiling Point: 377.3°Cat760mmHg
• Flash Point: 182°C
• Appearance: /
• Density: 1.751g/cm³
• Vapor Pressure: 6.83E-06mmHg at 25°C
• Refractive Index: 1.623
• PKA: 8.91±0.10(Predicted)
• CAS DataBase Reference: 4-BROMOBENZENESULFONOHYDRAZIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMOBENZENESULFONOHYDRAZIDE(2297-64-5)
• EPA Substance Registry System: 4-BROMOBENZENESULFONOHYDRAZIDE(2297-64-5)

Safety Data

• Hazardous Substances Data: 2297-64-5(Hazardous Substances Data)

Usage

General Description

4-Bromobenzenesulfonohydrazide, also known as 4-bromo-1-benzenesulfonylhydrazine, is a chemical compound with the formula C6H6BrN3O2S. It is a white to light beige crystalline powder that is used as a reagent in organic synthesis. 4-Bromobenzenesulfonohydrazide is primarily used as a reactant in the preparation of a variety of compounds, including potential pharmaceuticals and agrochemicals. It is also a key intermediate in the production of dyes and pigments. 4-BROMOBENZENESULFONOHYDRAZIDE is known for its ability to undergo various chemical reactions, including nucleophilic substitution and oxidative coupling, making it a versatile building block in the synthesis of complex organic molecules. However, it should be handled with care, as it is considered a hazardous material and should be used in a well-ventilated area with appropriate protective equipment.

InChI:InChI=1/C6H7BrN2O2S/c7-5-1-3-6(4-2-5)12(10,11)9-8/h1-4,9H,8H2

Upstream product

• 98-58-8 4-bromobenzenesulfonyl chloride 

Downstream Products

• 115273-37-5 4-bromo-benzenesulfonic acid-(N'-ξ-D-ribopyranosyl-hydrazide) 
• 108630-26-8 4-bromo-benzenesulfonic acid-(N'-ξ-D-glucopyranosyl-hydrazide) 
• 219711-56-5 2-(4-bromo-benzenesulfonyl)-6-hydroxy-2H-pyridazin-3-one 
• 6647-79-6 N'-benzylidene-4-bromobenzenesulfonohydrazide 
• 1244620-34-5 4-bromo-N'-(diphenylmethylene)benzenesulfonohydrazide 
• 1083236-25-2 2-choloro-3-(4-bromophenylsulfonyl)quinoxaline 
• 1345670-31-6 2-(3-hydroxyphenylamino)-3-(4-bromophenylsulfonyl)quinoxaline 
• 1345670-32-7 2-(4-fluorophenylamino)-3-(4-bromophenylsulfonyl)quinoxaline 
• 1203551-17-0 2-(4-chlorophenylamino)-3-(4-bromophenylsulfonyl)quinoxaline 
• 1454773-59-1 (E)-1-bromo-4-((2-bromo-2-phenylvinyl)sulfonyl)benzene 
• 41024-50-4 2-((4-bromophenyl)sulfonyl)-1-phenylethan-1-one 
• 1554261-67-4 C₁₆H₁₇BrOS 
• 27691-25-4 (E)-1-bromo-4-((4-methylstyryl)sulfonyl)benzene 
• 92-86-4 4-(4-bromophenyl)bromobenzene 

Relevant articles and documents

Synthesis and anticancer activity of novel hydrazone linkage-based aryl sulfonate derivatives as apoptosis inducers

In the present study, the various 28 hybrid molecules containing hydrazone and sulfonate moieties were synthesized and characterized by FTIR, 1H-NMR, 13C-NMR spectroscopy and LC-MS spectrometry, besides elemental analysis. The compou

Palladium-Catalyzed Direct C-H Arylation of 3-Butenoic Acid Derivatives

We report herein a direct method to synthesize 4-aryl-3-butenoic acid through a carboxylic-acid-directed oxidative Heck reaction. The various 4-aryl-3-butenoic acids are easily prepared in moderate to good yields. In view of the promising bioactivity of 4-phenyl-3-butenoic acid previously reported, its derivatives reported here may be bioactive.

Electrochemical heterodifunctionalization of α-CF3alkenes to access α-trifluoromethyl-β-sulfonyl tertiary alcohols

An unprecedented electrochemical heterodifunctionalization of α-CF3alkenes with benzenesulfonyl hydrazides was accomplished in this work, wherein a β-sulfonyl and a α-hydroxyl group were simultaneously incorporated across the olefinic double bond in a single operation. Consequently, a series of potentially medicinally valuable and densely functionalized α-trifluoromethyl-β-sulfonyl tertiary alcohols were assembled under mild conditions. Electrochemically-driven oxidative 1,2-difunctionlization of electron-deficient alkenes well obviates the need for oxidizing reagents, thus rendering this protocol more eco-friendly.