22976-86-9 Usage
Description
Polyoxin D is a member of the polyoxin class, which is a type of antibiotic. It is specifically isolated from the soil organism Streptomyces cacaoi var. asoensis. POLYOXIN D exhibits fungicidal properties, making it a valuable tool in controlling fungal growth in various settings.
Uses
Used in Agriculture:
Polyoxin D is used as a fungicide for the control of fungal infections in rice crops. Its specific inhibition of fungal chitin synthetase helps protect the plants from diseases caused by fungi.
Used in Industrial and Recreational Landscaping:
Polyoxin D is also used as a fungicide in industrial grounds, golf courses, and parks. It helps maintain the health and appearance of the vegetation by preventing fungal growth and the spread of fungal diseases.
Enzyme inhibitor
This pyrimidin nucleoside analogue and antifungal antibiotic (FWfree-acid = 521.39 g/mol; CAS 22976-86-9; 33401-46-6 for the zinc salt), produced by soil organisms Streptomyces cacaoi and S. piomogenus, inhibits chitin biosynthesis, Ki = 6 μM, thereby blocking septum formation. The zinc salt of polyyoxin is used to control Rice Sheath Blight, caused by the fungus Rhizoctonia solani, as well as the turfgrass disease Brown Patch, caused by other Rhizoctonia species. Polyoxin D also inhibits Neurospora crassa, but is nontoxic to land mammals, insects, or birds, when applied to plants as the wettable powder form known as Endorse?. Target(s): chitin synthase (1- 24); chitin synthase B; chitin synthase, canChs1A; WdChs4p, a chitin synthase 3 homologue.
Check Digit Verification of cas no
The CAS Registry Mumber 22976-86-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,2,9,7 and 6 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 22976-86:
(7*2)+(6*2)+(5*9)+(4*7)+(3*6)+(2*8)+(1*6)=139
139 % 10 = 9
So 22976-86-9 is a valid CAS Registry Number.
InChI:InChI=1/C17H23N5O14/c18-5(7(24)4(23)2-35-16(19)33)12(28)20-6(15(31)32)10-8(25)9(26)13(36-10)22-1-3(14(29)30)11(27)21-17(22)34/h1,4-10,13,23-26H,2,18H2,(H2,19,33)(H,20,28)(H,29,30)(H,31,32)(H,21,27,34)/t4-,5-,6-,7+,8-,9+,10+,13+/m0/s1
22976-86-9Relevant articles and documents
First total syntheses of (+)-polyoxin B and (+)-Polyoxin D
Uchida, Kimio,Kato, Keisuke,Yamaguchi, Kentaro,Akita, Hiroyuki
, p. 2253 - 2259 (2007/10/03)
First total syntheses of the peptidyl nucleoside antibiotics, polyoxins B (1) and D (2), are achieved based on the coupling reactions of the N-protected L-carbamoyl-polyoxamic acid derivative (6) with polyoxin C (8), 6 with polyoxin C acid (9), respectively.
