22977-65-7

Usage

Uses

Used in Pharmaceutical Applications:
4-PalMitaMido-2,2,6,6-tetraMethylpiperidine-1-oxyl is used as a research compound for studying the interactions between membranes and various molecules. Its amphiphilic nature and ability to bind strongly to membranes make it a valuable tool for investigating electrostatic potentials and lipid-protein interactions at the membrane surface.
Used in Chemical and Material Science:
In the field of chemical and material science, 4-PalMitaMido-2,2,6,6-tetraMethylpiperidine-1-oxyl is used as a stable radical for the development and study of new materials with unique properties. Its ability to bind to membranes and localize the nitroxide function in the aqueous phase can be exploited to create materials with specific interactions and functionalities.
Used in Analytical Chemistry:
4-PalMitaMido-2,2,6,6-tetraMethylpiperidine-1-oxyl is used as an analytical tool for studying the properties of membranes and their interactions with other molecules. Its unique structure allows for the investigation of electrostatic potentials and lipid-protein interactions, providing valuable insights into the behavior of biological membranes and their role in various processes.
Used in Nanotechnology:
In nanotechnology, 4-PalMitaMido-2,2,6,6-tetraMethylpiperidine-1-oxyl is used as a component in the design and synthesis of novel nanoparticles with specific targeting and interaction properties. Its amphiphilic nature and ability to bind to membranes can be utilized to create nanoparticles that can selectively interact with biological membranes, potentially leading to applications in drug delivery and targeted therapies.

Upstream product

• 14691-88-4 4-amino-2,2,6,6-tetramethyl-1-piperidine-1-oxyl 
• 57-10-3 1-hexadecylcarboxylic acid 

Relevant academic research and scientific papers

Critical temperature and le/g phase transitions in monolayer films of the amphiphilic tempo derivatives at the air/water interface

Phase behavior of five members of a homologous series of 4-alkaneamido-2,2,6,6-tetramethyl-1-piperidinyloxy (CnTEMPO with n = 14, 16, 18, 20, 22) was investigated with classical Langmuir monolayer techniques and with Brewster angle microscopy and 2D voltammetry. Surface potential data, BAM images, and 2D voltammetry showed that only C20- and C22TEMPO monolayers have a 2D LE/G critical point above room temperature and that the remaining three compounds with shorter alkane chains form supercritical monolayers. The unusually low values of the critical temperature for these amphiphiles was explained in terms of the molecular structure of their headgroup featuring two polar groups (the nitroxy and the amide moieties) located in the opposite positions of a bulky piperidine ring. The presence of the two polar groups causes a change of orientation of the headgroup during monolayer expansion and results in a substantial increase (ca. 50-100 Aì?2/molecule) of the cross sectional area of these amphiphiles. As a result, in the expanded monolayers, the van der Waals attraction between the alkane chains is weakened as they can only partially align. The decreased cohesion within the monolayers leads to the observed decrease of their 2D critical temperature. Analysis of the plots of BAM reflected light intensity as a function of amphiphile's surface concentration obtained at different temperatures yielded the C20TEMPO critical temperature of 28 ?°C. BAM and 2D voltammetry can both be used to precisely determine the position of the C22TEMPO LE/G phase transition (98.5 Aì?2/molecule at 23.5 ?°C). The proximity of the C20TEMPO critical point to the room-temperature results in a less precise value of this phase transition (127-130 Aì?2/molecule at 23.5 ?°C). A remarkably consistent ability of fresh line microelectrodes used in 2D voltammetry to nucleate the 2D gas phase makes this method less ambiguous and thus superior to BAM in determining the position of the LE/G phase transitions.

Molecular mobility and rate of oxidation of nitroxyl radicals in micellar and homogeneous systems

The relation between the rate of oxidation of the nitroxyl radical by tetranitromethane and the rotational correlation time of the radical was investigated by EPR spectroscopy (the water-t-butyl alcohol homogeneous mixture and micellar solutions based on Tritons X100 and WR1339 were used as solvents).The results led to the conclusion that there is a clear correlation between the rate constant and the rotational mobility.The results were subjected to theoretical analysis according to the indirect cage effect model.