22977-67-9

Usage

Uses

Used in Organic Synthesis:
TEMPO is used as a catalyst in the oxidation of alcohols to aldehydes and ketones, enabling the selective conversion of alcohols into valuable intermediates in organic chemistry. Its ability to facilitate controlled oxidation reactions makes it a preferred choice for chemists.
Used in Functionalization of Organic Compounds:
TEMPO is employed in the functionalization of various organic compounds, allowing for the introduction of new functional groups and the modification of existing ones. This versatility makes TEMPO a valuable tool in the synthesis of complex organic molecules and the development of new materials.
Used in Polymer Industry:
In the polymer industry, TEMPO is utilized as a radical initiator in the production of polymers and copolymers. Its ability to generate stable radicals facilitates the controlled polymerization process, leading to the formation of polymers with desired properties and structures.
Used in Material Science:
TEMPO has gained significant attention in material science due to its potential applications in the development of new materials with unique properties. Its ability to participate in various chemical reactions and its compatibility with a wide range of organic solvents make it a promising candidate for the synthesis of advanced materials.

Upstream product

• 45985-24-8 TEMPOL 
• 57-11-4 stearic acid 
• 112-76-5 Stearoyl chloride 
• 2564-83-2 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical 

Relevant academic research and scientific papers

Ultrasound-Responsive Nanoparticulate for Selective Amplification of Chemotherapeutic Potency for Ablation of Solid Tumors

Precision medicine requests preferential transportation of the pharmaceutical substances to the pathological site and impartation of localized therapeutic activities to the targeted cells. To accomplish this goal, we attempted a facile nanoscaled ultrasound-responsive delivery system, characterized by doxorubicin assembled with an amphiphilic copolymer (multiple of hydrophobic stearic segments tethered onto the hydrophilic pullulan backbone through ultrasound-labile oxyl-alkylhydroxylamine linkage). As a consequence of the strategically installed ultrasound-labile oxyl-alkylhydroxylamine linkage to elicit the tailored segregation of the hydrophilic pullulan and the hydrophobic stearic segments upon ultrasound impetus, the constructed nanoscaled self-assembly presented distinctive structural destabilization behaviors and afforded spatiotemporal controlled liberation of the cytotoxic drugs. It is worthy to note that the ultrasound was determined to markedly lower the IC50 of the proposed system from over 10 μg/mL to 2.33 μg/mL (approximate 4-fold), thereby serving as a facile impetus to amplify the cytotoxic potency of the proposed drug delivery vehicles. Furthermore, drastic tumor ablation was validated by dosage of the proposed doxorubicin delivery system to T41 tumor-bearing mice accompanied by the tumor-localized ultrasound impetus, while no observable adverse side effect was confirmed. Therefore, the results advocated our ultrasound-responsive delivery vehicle as a tempting strategy for precise spatiotemporal control of the release of the drug cargo, thus affording selectively amplified cytotoxic potency to the ultrasound-imposed site, which should be highlighted as important progress toward precision medicine.

Drug carrier with liver-targeted intelligent ultrasonic response drug release function as well as preparation method and application thereof

The invention belongs to the technical field of biological materials and relates to a drug carrier with a liver-targeted intelligent ultrasonic response drug release function as well as a preparationmethod and the application thereof. The drug carrier consists of an amphiphilic block copolymer pLAMA-OC; polymer molecules containing galactose residues are used as a hydrophilic shell, stearic acidmolecules are used as a hydrophobic core, and a hydrophobic drug is encapsulated in the hydrophobic core of the drug carrier under the hydrophobic action; when the polymer molecules of the hydrophilicshell are coupled with hydrophobic molecules of the hydrophobic core, a ultrasound sensitive chemical bond is formed, so that the drug carrier has the ultrasonic response drug release function. Through combining the active targeting ability given by the galactose residues to the carrier with the time-space controlled drug release ability of the ultrasonic sensitive chemical bond, the leakage of the drug in the drug carrier in the blood circulation can be reduced, the uptake of the drug carrier in liver cancer cells is increased, the concentration of an anti-cancer drug in liver cancer cells is quickly improved, the cancer cells are quickly killed, and the drug resistance is avoided. Therefore, the drug carrier has an application value in the field of biomedical materials.

Inhibiting polymerization of vinyl aromatic monomers

When a nitroxyl compound is heated in an oxygen-free atmosphere with a vinyl aromatic monomer at 50-140 DEG C. for up to 60 days, it forms an activated inhibitor mixture which is superior to the nitroxyl compound itself in preventing the premature polymerization of a vinyl aromatic monomer during its processing and purification.

Polymerization inhibition of acrylates using blends of nitroxides

Ethylenically unsaturated carboxyl monomers, such as acrylic or methacrylic acid or their esters, are protected from premature polymerization during manufacture and storage in the presence or absence of water by the incorporation therein of an effective stabilizing amount of a blend two or more nitroxides. Some of these blends provide synergistic stabilization efficacy much superior to the stabilization results obtained by use of either nitroxide alone.

A convenient acylation procedure of alcohols and amines

The reaction of carboxylic acids with primary and secondary alcohols in the presence of aromatic sulfochlorides (mesitylenesulfonyl chloride and 2,4,6-triisopropylbenzenesulfonyl chloride) or aromatic sulfotetrazoles (mesytilenesulfonyl tetrazolide and 2,4,6-triisopropylbenzenesulfonyltetrazole) and usual acylation catalysts was shown to be a convenient procedure for the synthesis of esters. Reaction of carboxylic acids with primary aliphatic or aromatic amines in the presence of the same tetrazolides and catalysts is a useful procedure for the synthesis of amides. Syntheses of twenty compounds are presented as examples.

Method for inhibiting premature polymerization of vinyl aromatic monomers

Nitroxyl inhibitors in combination with some oxygen reduce the premature polymerization of vinyl aromatic monomers during the manufacturing processes for such monomers. Even small quantities of air used in combination with the nitroxyl inhibitors result in vastly prolonged inhibition times for said monomers.

Inhibiting polymerization of vinyl aromatic monomers

The polymerization of a vinyl aromatic compound, such as styrene, during distillation or purification is very effectively inhibited by the presence of at least one stable nitroxyl compound together with at least one aromatic nitro compound.