22991-47-5Relevant academic research and scientific papers
2-Hydroxy-5-nitrobenzyl as a diazeniumdiolate protecting group: Application in no-releasing polymers with enhanced biocompatibility
Xu, Hua,Reynolds, Melissa M.,Cook, Keith E.,Evans, Anthony S.,Toscano, John P.
supporting information; experimental part, p. 4593 - 4596 (2009/05/07)
(Chemical Equation Presented) The 2-hydroxy-5-nitrobenzyl group is shown to be an effective protecting group for diazeniumdiolates. O2-(2- Hydroxy-5-nitrobenzyl)-substituted diazeniumdiolates display enhanced thermal stability, but efficiently release nitric oxide (NO) in pH 7.4 aqueous solutions. A lipophilic analogue incorporated into hydrophobic polymers shows NO surface flux rates comparable to that of the natural endothelium. Importantly, these polymer formulations also show significantly enhanced biocompatibility in vivo with use of a porcine implant model.
Synthesis and reactions of nitro derivatives of hydrogenated cardanol
Attanasi, Orazio A.,Berretta, Stefano,Fiani, Cinzia,Filippone, Paolino,Mele, Giuseppe,Saladino, Raffaele
, p. 6113 - 6120 (2007/10/03)
3-n-Pentadecylphenol (hydrogenated cardanol) and its derivative 5-n-pentadecyl-2-tert-butylphenol can be nitrated using nitric acid in acetonitrile or methanol to give mono, di or trinitro products. 5-n-Pentadecyl-2-nitrophenol undergoes reductive carbonylation to give a benzoxazole-2-one derivative. An efficient catalytic oxidation reaction in the presence of MeReO3 has also been studied.
