229971-77-1

Basic information

• Product Name: Carbamic acid, [(1S)-2-oxo-1-[(phenylmethoxy)methyl]-2-[(phenylmethyl)amino]ethyl]-, 1,1-dimethylethyl ester
• CAS NO: 229971-77-1
• Molecular Formula: C22H28N2O4
• Molecular Weight: 384.475
• Mol File: 229971-77-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [(1S)-2-oxo-1-[(phenylmethoxy)methyl]-2-[(phenylmethyl)amino]ethyl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [(1S)-2-oxo-1-[(phenylmethoxy)methyl]-2-[(phenylmethyl)amino]ethyl]-, 1,1-dimethylethyl ester(229971-77-1)
• EPA Substance Registry System: Carbamic acid, [(1S)-2-oxo-1-[(phenylmethoxy)methyl]-2-[(phenylmethyl)amino]ethyl]-, 1,1-dimethylethyl ester(229971-77-1)

Safety Data

• Hazardous Substances Data: 229971-77-1(Hazardous Substances Data)

Upstream product

• 23680-31-1 BOC-O-benzyl-L-serine 
• 100-46-9 benzylamine 
• 125814-31-5 (S)-4-Benzyloxymethyl-2,5-dioxo-oxazolidine-3-carboxylic acid tert-butyl ester 

Relevant articles and documents

Catalytic reductive N-alkylation of amines using carboxylic acids

We report a catalytic reductive alkylation reaction of primary or secondary amines with carboxylic acids. The two-phase process involves silane mediated direct amidation followed by catalytic reduction.

Direct synthesis of acyl azides from carboxylic acids using 2-azido-l,3-dimethylimidazolinium chloride

Acyl azides were directly synthesized from carboxylic acids by the treatment with 2-azido-l,3-dimethylimidazolinium chloride (ADMC, 1) and amine. This procedure resulted in acyl azides in good yields and was applied to the amidation of amino acid derivatives without racemization of the products.

3-(Diethoxyphosphoryloxy)-1,2,3-benzotriazin-4(3H)-one (DEPBT): a new coupling reagent with remarkable resistance to racemization.

[formula: see text] The new crystalline phosphate reagent 3-(diethoxyphosphoryloxy)-1,2,3-benzotriazin-4(3H)-one (DEPBT) mediates amide bond formation with a remarkable resistance to racemization. Comparative racemization studies were carried out and DEPBT proved to be superior to typical phosphonium and uronium coupling reagents. DEPBT is easily prepared and is exceedingly stable with a shelf life of months at room temperature. The advantageous properties of DEPBT render it a useful and unique addition to the arsenal of coupling reagents.