229981-12-8Relevant articles and documents
MU OPIOID RECEPTOR LIGANDS: METHODS OF USE AND SYNTHESIS
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Page 49, (2008/06/13)
Peptidomimetic compounds derived from aralkyl substitued 8-amino-3,7- or 3,6-dihydroxy alkenoic or alkanoic acids and compositions including those compounds, as well as methods of using and making the compounds are herein described. The compounds are usef
High-affinity mu opioid receptor ligands discovered by the screening of an exhaustively stereodiversified library of 1,5-enediols
Harrison, Bryce A.,Gierasch, Tiffany Malinky,Neilan, Claire,Pasternak, Gavril W.,Verdine, Gregory L.
, p. 13352 - 13353 (2007/10/03)
In this communication, we report the synthesis of an exhaustively stereodiversified library of 16 1,5-enediols (2) and the screening of these compounds for mu opioid receptor (MOR) binding. The stereochemical configuration of 2 strongly impacted the bindi