23000-46-6

Usage

Chemical classification

Pyrazolopyrimidine derivative It belongs to a group of compounds derived from the pyrazolopyrimidine core structure.

Contains a phenyl group

Aromatic functional group (C6H5) This group is known for its stability and is commonly found in various pharmaceuticals and organic compounds.

Contains a piperidine group

Cyclic amine structure (C5H10N) This group is a five-membered cyclic amine and is found in many natural products and pharmaceuticals.

Contains a pyrazolopyrimidine ring

A heterocyclic ring system with one pyrazole and one pyrimidine ring This ring system is responsible for the compound's potential biological activities.

Potential pharmaceutical applications

Biological activities Although further research is needed, 1-phenyl-4-(piperidine-1-yl)-1H-pyrazolo[3,4-d]pyrimidine may have potential uses in the pharmaceutical industry due to its unique structure and properties.

Precautions

Handle with care As the precise effects and potential hazards of 1-phenyl-4-(piperidine-1-yl)-1H-pyrazolo[3,4-d]pyrimidine are not yet fully understood, it is important to handle and use this chemical with caution.

Upstream product

• 591-50-4 iodobenzene 
• 21314-17-0 1-phenyl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one 
• 110-89-4 piperidine 

Relevant academic research and scientific papers

Pyrazolopyrimidine compound and pharmaceutical composition, preparation method and application thereof

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to a pyrazolopyrimidine compound and a preparation method thereof, and further specifically relates to a pharmaceutical composition. The pharmaceutical composition mainly comprises an active component pyrazolopyrimidine small molecule compound and a pharmaceutical excipient for inhalation administration, and the pyrazolopyrimidine small molecule compound comprises the pyrazolopyrimidine compound. The invention also relates to an application of the pyrazolopyrimidine compound or the preparationmethod thereof in treatment of cardiopulmonary vascular diseases, and an application of the pharmaceutical composition in treatment of cardiopulmonary vascular diseases. The preparation process of the pyrazolopyrimidine compound is simple and single in product. According to the pharmaceutical composition preparation, the limitation of bioactive molecules is avoided, the absorption effect of the inhalation preparation in an animal body is obvious, the pharmaceutical composition preparation has an obvious treatment advantage when applied to pulmonary hypertension, the research and development prospect is good, and the pharmaceutical composition preparation is expected to become a new pulmonary hypertension targeting drug and is low in synthesis cost and easy to store and transport.

The one-pot conversion of pyrimidinone derivatives into substituted pyrimidines using diphenylphosphinic chloride under a mild condition

Pyrimidinone derivatives reacted with diphenylphosphinic chloride followed by addition of nucleophiles to afford substituted pyrimidine derivatives at a mild temperature (20-66°C).