23008-77-7

Usage

Uses

Used in Food and Beverage Industry:
Ethyl 3-(2-hydroxyphenyl)-3-oxopropanoate is used as a flavoring agent for its sweet and fruity aroma, enhancing the taste and aroma of various food and beverage products.
Used in Perfume and Fragrance Industry:
Ethyl 3-(2-hydroxyphenyl)-3-oxopropanoate is used as a key ingredient in the production of perfumes and fragrances, contributing to their unique and pleasant scents.

Upstream product

• 118-93-4 o-hydroxyacetophenone 
• 105-58-8 Diethyl carbonate 
• 1076-38-6 4-hydroxy[1]benzopyran-2-one 
• 64-17-5 ethanol 
• 623-73-4 diazoacetic acid ethyl ester 
• 90-02-8 salicylaldehyde 

Downstream Products

• 29360-84-7 amino-2 (hydroxy-2 phenyl)-6 oxo-4 dihydro-3,4 pyrimidine 
• 38210-27-4 frutinone A 
• 1207514-77-9 (E)-ethyl 3-(3-(benzyloxy)-4-methoxyphenyl)-2-(2-hydroxybenzoyl)acrylate 
• 1207514-70-2 (E)-ethyl 3-(2-bromophenyl)-2-(2-hydroxybenzoyl)acrylate 
• 1207514-72-4 (E)-ethyl 3-(biphenyl-4-yl)-2-(2-hydroxybenzoyl)acrylate 
• 1207514-68-8 (E)-ethyl 3-(4-cyanophenyl)-2-(2-hydroxybenzoyl)acrylate 
• 1207514-73-5 (E)-ethyl 2-(2-hydroxybenzoyl)-3-(naphthalen-2-yl)acrylate 

Relevant academic research and scientific papers

One-pot synthesis of 3-(furan-2-yl)-4-hydroxy-2H-chromen-2-ones using K10 montmorillonite clay as heterogeneous catalyst

A facile and efficient one-pot synthesis of 3-(furan-2-yl)-4-hydroxy-2H-chromen-2-ones was developed. The reaction of ethyl 3-(2-hydroxyphenyl)-3-oxopropanoates and 2,5-dimethoxy-2,5-dihydrofuran were performed in presence of K10 Montmorillonite Clay hete

Construction of trisubstituted chromone skeletons carrying electron-withdrawing groups via PhIO-mediated dehydrogenation and its application to the synthesis of frutinone A

The construction of the biologically interesting chromone skeleton was realized by PhIO-mediated dehydrogenation of chromanones under mild conditions. Interestingly, this method also found application in the synthesis of the naturally occurring frutinone A.

Triketone organic compound, preparation method and application thereof

The invention discloses a triketone organic compound, a preparation method and application thereof. A concrete synthesis method comprises the steps of reacting hydroxyacetophenone and dimethyl carbonate or diethyl carbonate to obtain a product 3-(2-hydroxyphenyl)-3-oxo ethyl propionate or 3-(2-hydroxyphenyl)-3-oxo methyl propanoate; reacting the product and benzaldehyde to obtain a product 4-oxo-2-phenyl benzo dihydropyran-3-carboxylic ethyl ester or 4-oxo-2-phenyl benzo dihydropyran-3-carboxylic acid methyl ester; then reacting the product and hydroxyacetophenone to obtain 1-(2-hydroxyphenyl)-3-(2-phenyl benzo dihydropyran-4-keto)-1,3-propanedione. The organic compound can be combined with rare earth ion so as to emit intense red light, and has a potential application value in the medical field.

Novel tripodione ligand organic compound and preparation method and application thereof

The invention discloses a novel tripodione ligand organic compound and a preparation method thereof. The preparation method comprises the following steps: subjecting o-hydroxyacetophenone to a reaction with diethyl carbonate or dimethyl carbonate so as to obtain a product, i.e., 3-(2-hydroxylphenyl)-3-oxo-ethyl propionate or 3-(2-hydroxylphenyl)-3-oxo-methyl propionate; subjecting the product to a reaction with benzaldehyde so as to obtain a product, i.e., 4-oxo-2-phenylbenzodihydropyran-3-ethyl carboxylate or 4-oxo-2-phenylbenzodihydropyran-3-methyl carboxylate; then, subjecting the product to a reaction with o-hydroxyacetophenone so as to obtain 1-(2-hydroxylphenyl)-3-(4-oxo-2-phenylbenzodihydropyran-3-yl)propan-1,3-dione; finally, carrying out a reaction with benzaldehyde, thereby obtaining 3,3'-carbonyl bis(2-phenylbenzodihydropyran-4-one). The organic compound can be bonded to rare-earth ions to emit intensive red light and will have a potential application value in the field of medicines.

Geranyl Geranyl Acetone Analogs and Uses Thereof

The invention relates to novel therapeutic compounds, more in particular to biologically active analogs and uses thereof as medicament, for instance for the treatment of atrial fibrillation. Provided is a compound of the general formula (formula I) wherein R1 is H or a saturated or unsaturated aliphatic moiety comprising 1 to 8 C-atoms; and X is selected from the group consisting of moieties X1, X2, X3, X4, X5 and X6. Exemplary uses include the prevention or therapeutic treatment of a HSF1-mediated disease.

GERANYL GERANYL ACETONE ANALOGS AND USES THEREOF

Title: Geranyl geranyl acetone analogs and uses thereof. Abstract The invention relates to novel therapeutic compounds, more in particular to biologically active analogs and uses thereof as medicament, for instance for the treatment of atrial fibrillation. Provided is a compound of the general formula wherein R1 is H or a saturated or unsaturated aliphatic moiety comprising 1 to 8 C- atoms; and X is selected from the group consisting of moieties X1, X2, X3, X4, X5 and X6. Exemplary uses include the prevention or therapeutic treatment of a HSF1-mediated disease.

GERANYL GERANYL ACETONE ANALOGS AND USES THEREOF

The invention relates to novel therapeutic compounds, more in particular to biologically active analogs and uses thereof as medicament, for instance for the treatment of atrial fibrillation. Provided is a compound of the general formula (formula I) wherein R1 is H or a saturated or unsaturated aliphatic moiety comprising 1 to 8 C- atoms; and X is selected from the group consisting of moieties X1, X2, X3, X4, X5 and X6. Exemplary uses include the prevention or therapeutic treatment of a HSF1-mediated disease.

Unusual anion effects in the iron-catalyzed formation of 3-hydroxyacrylates from aromatic aldehydes and ethyl diazoacetate

Due to the lability of one of the CO ligands in irans-[Fe(PNP)(CO) 2Cl]+ this compound is an efficient catalyst for the coupling of a series of aromatic aldehydes with ethyl diazoacetate (EDA), which give, in most cases, selectively 3-hydroxyacrylates rather than β-oxo esters. This reaction is strongly dependent on the nature of the counterion, Whereas with BF4- the reaction proceeds with conversions up to 90%, in the case of the counterions NO3-, CF 3COO-, CF3SO3-, SbF 6-, and BAr'4- [Ar' = 3,5-(CF 3)2C6H3] no reaction took place. In the case of PF6- only up to 20% conversion was achieved. A conceivable mechanism for the coupling of aromatic aldehydes with EDA was established by means of DFT/B3LYP calculations, which allowed the rationalization of both the chemoselectivity and the role of the counterions.

Synthesis and Protein-Tyrosine Kinase Inhibitory Activities of Flavanoid Analogues

Treatment of o-hydroxyacetophenones 2a-e with excess lithium bis(trimethylsilyl)amide followed by dialkyl carbonates gave 3-(2-hydroxyaryl)-3-oxopropanoates 3a-e.The latter substances were transformed through the reaction of their magnesium chelates with

BETA-ADRENERGIC BLOCKING AGENTS IN THE 1,2,3-THIADIAZOLE SERIES

Novel 4-2,3 or 4(3-amino-2-hydroxypropoxy) phenyl!-and 5-2, 3 or 4(3-amino-2-hydroxypropoxy) phenyl!-1,2,3-thiadiazole derivatives which may be further substituted at the C-5 or C-4 position of the thiadiazole ring, respectively, by a lower alkyl, phenyl, trifluoromethyl, carboxy, alkoxycarbonyl, cyano or an aminocarbonyl group, and the pharmaceutically acceptable acid addition salts thereof and processes for the production of such compounds; 4-4(3-t-butylamino-2-hydroxypropoxy) phenyl!-1,2,3-thiadiazole and 5-4(3-t-butylamino-2-hydroxypropoxy) phenyl!-1,2,3-thiadiazole are representative of the class. These compounds possess cardiovascular activity and are useful for the treatment of abnormal heart conditions in mammals.