23009-38-3Relevant academic research and scientific papers
Reliable and general method for the cleavage of α-arylheteroatom- substituted carboxylic acids
Spurg, Anke,Waldvogel, Siegfried R.
, p. 3042 - 3044 (2007)
Bonds between arylheteroatom moieties and α-carbons of carboxylic acids are efficiently cleft by azide transfer and subsequent Curtius rearrangement. The scope of the one-pot protocol covers differently substituted carboxylic acids and heteroatoms like O, S, Se, and N. Georg Thieme Verlag Stuttgart.
Antitumour imidazotetrazines. Part 39. Synthesis of bis(imidazotetrazine)s with saturated spacer groups
Arrowsmith, Jill,Jennings, Sharon A.,Langnel, David A.F.,Wheelhouse, Richard T.,Stevens, Malcolm F. G.
, p. 4432 - 4438 (2000)
Bis(imidazotetrazine)s (16), related in structure to the antitumour agents mitozolomide (1a) and tempzolomide (1b), but linked through the N(3)-N(3′) atoms of the imidazo[5, 1-d][1,2,3,5]tetrazine ring-systems, are prepared by interaction of 5-diazoimidazole-4-carboxamide (8) and diisocyanates (15). The presence of the polymethylene linker with/without sulfur and oxygen heteroatoms does not substantially affect the acid stability, base-catalysed decomposition, antitumour activity or DNA base alkylation preference characteristic of the unlinked imidazotetrazines mitozolomide and temozolomide., The Royal Society of Chemistry 2000.
