2301-36-2

Usage

Derivative of

Imidazolidinedione

Side Group

Phenylmethyl

Usage

Organic synthesis
Pharmaceutical research

Function

Building block for various drugs and biologically active molecules

Applications

Preparation of pharmaceutical compounds
Potential therapeutic applications
Other industrial applications and chemical processes

Upstream product

• 302-72-7 rac-Ala-OH 
• 3173-56-6 benzyl isothiocyanate 
• 22003-17-4 O-phenyl N-benzylcarbamate 
• 2491-20-5 L-alanine methyl ester hydrochloride 

Downstream Products

• 85369-81-9 cis-3-benzyl-5-methyl-4-hydroxy-2-imidazolidinone 
• 85369-82-0 trans-3-benzyl-5-methyl-4-hydroxy-2-imidazolidinone 
• 85369-91-1 N¹-benzyl-N²-methylpropane-1,2-diamine 

Relevant academic research and scientific papers

Facile One-Pot Synthesis of Substituted Hydantoins from Carbamates

A novel and simple approach for the preparation of 3-substituted, 5-substituted, or 3,5-disubstituted hydantoins is reported. It involves the reaction of α-amino methyl ester hydrochlorides with carbamates to yield the corresponding ureido derivatives, which subsequently cyclize under basic conditions to produce substituted hydantoins in good yields. By applying this method, the bioactive anticonvulsant drug ethotoin was synthesized in good yield. The process avoids conventional multistep protocols and does not use the hazardous, irritant, toxic, or moisture-sensitive reagents, such as isocyanates or chloroformates, that are commonly used for the synthesis of these important compounds.

Functionalized amino acid anticonvulsants: Synthesis and pharmacological evaluation of conformationally restricted analogues

Proven conformationally restricted analogues of anticonvulsant functionalized amino acids (FAAs) were prepared using short-range cyclizations and evaluated in pharmacological assays providing new information concerning the structural requirements for FAA function.