2302-95-6

Usage

Uses

Used in Pharmaceutical Industry:
(1E)-3-amino-1-ethylidene-thiourea is used as a pharmaceutical intermediate for the synthesis of various organic compounds, contributing to the development of new drugs and therapeutic agents.
Used in Diabetes Management:
(1E)-3-amino-1-ethylidene-thiourea is used as an inhibitor of advanced glycation end products, which are associated with diabetes and other age-related diseases, helping to manage and treat these conditions.
Used in Antioxidant and Anti-inflammatory Research:
(1E)-3-amino-1-ethylidene-thiourea is used in research for its potential antioxidative and anti-inflammatory properties, exploring its applications in various fields of medicine and healthcare.

InChI:InChI=1/C3H7N3S/c1-2-5-3(7)6-4/h2H,4H2,1H3,(H,6,7)/b5-2+

Upstream product

• 75-07-0 acetaldehyde 
• 79-19-6 thiosemicarbazide 

Downstream Products

• 108-33-8 5-methyl-1,3,4-thiadiazol-2-amine 
• 1093187-53-1 [Cu2(μ-Br)2(η1-S-acetaldehyde thiosemicarbazone)2(Ph3P)2] 
• 144-82-1 sulfamethizole 

Relevant academic research and scientific papers

Spectroscopic analysis, AIM, NLO and VCD investigations of acetaldehyde thiosemicarbazone using quantum mechanical simulations

The prepared Acetaldehyde thiosemicarbazone (ATSC) have been investigated by both the experimental and theoretical methods; through this work, the essentiality of elucidation of molecular fragments source linear and non-linear optical properties was explo

Synthesis of Emodin Amide Derivatives Containing 1,3,4-Thiadiazole and Their Inhibitory Activity on Vibrio harveyi

A series of new 1,3,4-thiadiazole Emodin amide derivatives were synthesized through the connection of 5-substituted-1,3,4-thiadiazole-2-amine and Emodin carboxylic acids which were obtained by a two-step procedure starting from Emodin. Vibrio harveyi inhibition activities of the newly prepared compounds were evaluated. Results revealed that all compounds showed different degrees of inhibition on V. harveyi. Among them, compound 7a showed the best V. harveyi inhibition effect and the minimum inhibitory concentration (MIC) was 0.0625 mg/mL.

Expedient routes to 1,2,4-triazolinium salts

Concomitant S-alkylation and ketazonation of thiosemicarbazide in acetone eventually led to unanticipated ring closure and formation of (3-alkylthio)-1,2,4-triazolinium salts. This initial finding was complemented by employing another three representative aldehydes and ketones. Supplementarily, some respective intermediates have been isolated by stepwise synthetic procedures. In addition to the usual spectroscopic characterization, the structures of six 1,2,4-triazolinium heterocycles, as well as two unexpected by-products thereof have been characterized by single-crystal X-ray diffraction.

Monoazo thiazolotriazole disperse dye and preparation method thereof

The invention relates to a monoazo thiazolotriazole disperse dye compound which has a structural formula (I) and disperse dye made from the monoazo thiazolotriazole disperse dye compound. A monoazo thiazolotriazole heterocyclic structure (3N1S) is introdu

Synthesis, biological evaluation and molecular modeling study of thiadiazolo[3,2-a][1,3]diazepine analogues of HIE-124 as a new class of short acting hypnotics

A new series of 6,7-dihydro-[1,3,4]thiadiazolo[3,2-a][1,3]diazepine analogues were synthesized, and biological evaluated. Compound GS-62 (33) exhibited potent in?vivo short acting hypnotic activity with onset time, duration of sleep and therapeutic index of 6.4?±?0.2, 94.8?±?5.3?min, 6.62, respectively), in comparison to thiopental sodium (6). Compounds 33 did not show any sign of acute tolerance reported with the maintenance dose of 6. Meanwhile 33 potentiated the in?vivo hypnotic effect of 6 in an equimolar amounts (0.06?mmol) combination showing an onset and duration of 7.5?±?1.3, 62.5?±?5.9?min, respectively. This combination allowed the use of lower doses of both drugs to avoid the undesirable side effects. Docking studies revealed favorable interactions and binding to BDZ binding site of the GABAAreceptor especially with Arg87, Arg149, and Thr151 amino acid residues.

Synthesis and antimicrobial activities of novel 6-(1,3-thiazol-4-yl)-1,3- benzoxazol-2(3H)-one derivatives

Synthesis, characterization and investigation of antimicrobial activities of seven new 6-(1,3-thiazol-4-yl)-1,3-benzoxazol-2(3H)-ones are presented. Their structures were determined using 1H NMR, 13C NMR and elemental analyses. The compounds possess some biological activity against Gram-positive bacteria, especially against Micrococcus luteus belonging to opportunistic pathogens, with an MIC of 31.25 μg/mL.

A class of potent tyrosinase inhibitors: Alkylidenethiosemicarbazide compounds

A series of alkylidenethiosemicarbazide compounds were synthesized and their inhibitory effects on the diphenolase activity of mushroom tyrosinase were evaluated. The results showed that most of the synthesized compounds exhibited significant inhibitory activities. Especially, compound 1f was found to be the most potent inhibitor with IC50 value of 0.086 μM, suggesting that further development of such compounds may be of interest.