23022-79-9

Upstream product

• 456-27-9 4-nitrobenzenediazonium tetrafluoroborate 
• 5332-96-7 1-(4-nitrophenyl)propan-2-one 

Downstream Products

• 68055-01-6 C₂₁H₁₇Cl₂N₃O₃ 
• 1023716-98-4 6-chloro-2-methyl-3-(4-nitro-phenyl)-imidazo[1,2-b]pyridazine 
• 68055-06-1 C₂₁H₁₅Cl₂N₃O₂ 
• 95065-86-4 2-[2-(2-Methyl-allylsulfanyl)-phenyl]-5-(4-nitro-phenyl)-2H-pyrazole-3,4-dicarboxylic acid dimethyl ester 
• 95065-85-3 2-(4-Nitro-phenyl)-3-phenyl-4H-5-thia-1,9b-diaza-cyclopenta[a]naphthalene 
• 95065-91-1 3-(4-Nitro-phenyl)-3-(1-phenyl-propa-1,2-dienyl)-3H-benzo[1,3,4]thiadiazine 
• 95065-81-9 2-(4-Nitro-phenyl)-3a,4-dihydro-3H-5-thia-1,9b-diaza-cyclopenta[a]naphthalene 
• 95065-92-2 3-(2-Methyl-allyl)-3-(4-nitro-phenyl)-3H-benzo[1,3,4]thiadiazine 
• 95065-83-1 2-(4-Nitro-phenyl)-4H-5-thia-1,9b-diaza-cyclopenta[a]naphthalene 
• 95065-82-0 3a-Methyl-2-(4-nitro-phenyl)-3a,4-dihydro-3H-5-thia-1,9b-diaza-cyclopenta[a]naphthalene 
• 95065-87-5 3-Allyl-3-(4-nitro-phenyl)-3H-benzo[1,3,4]thiadiazine 
• 95065-90-0 3-(4-Nitro-phenyl)-3-propa-1,2-dienyl-3H-benzo[1,3,4]thiadiazine 
• 95065-77-3 C₁₆H₁₂ClN₃O₂S 
• 95065-78-4 C₂₂H₁₆ClN₃O₂S 

Relevant academic research and scientific papers

Salicylic Acid-Catalyzed Arylation of Enol Acetates with Anilines

α-Aryl ketones are both structure moieties commonly found in bioactive compounds and versatile synthetic intermediates for the preparation of drug-like molecules. An operationally simple and scalable protocol has been developed to prepare α-aryl ketones from readily available aromatic amines and enol acetates (or silyl enol ethers). This metal-free methodology features the use of salicylic acid as a convenient catalyst to promote the formation of aryl radicals from in-situ generated aryl diazonium salts, without demanding thermal or photochemical activation. The mild reaction conditions used are compatible with anilines substituted with diverse functionalities. Structural elaboration of some prepared α-aryl ketones was accomplished to illustrate their usefulness as building blocks. (Figure presented.).

A Simple and Efficient Method for the Preparation of α-Halogenated Ketones Using Iron(III) Chloride and Iron(III) Bromide as Halogen Sources with Phenyliodonium Diacetate as Oxidant

α-Halogenated ketones are both unique structure moieties existing in biologically natural products and valuable synthetic intermediates for the preparation of functional molecules. An efficient and scalable method for the preparation of α-halogenated ketone using iron (III) chloride and iron (III) bromide as halogen sources with phenyliodonium diacetate as oxidant has been developed, featuring mild reaction conditions, environmentally friendly reagents, and wide substrate scope. Notably, the three-step synthesis of drug prasugrel was achieved using this developed method as a key step with 30% yield on gram-scale. Additionally, the reaction mechanism involving chloride cation was proposed based on some preliminary control experiments. (Figure presented.).