230285-83-3

Upstream product

• 153253-02-2 (2R,3S,4S,5R,6R)-2-(acetoxymethyl)-6-(2-(((benzyloxy)carbonyl)amino)ethoxy) tetrahydro-2H-pyran-3,4,5-triyl triacetate 
• 77987-49-6 benzyl 2-hydroxyethylcarbamate 
• 86520-63-0 2,3,4,6-tetra-O-acetyl-α-galactopyranosyl trichloroacetimidate 
• 4163-60-4 β-D-galactose peracetate 
• 25878-60-8 D-galactose pentaacetate 
• 483362-46-5 benzyl 2-(2,3,4,6-O-tetra-benzoyl-β-D-galactopyranosyloxy)ethylcarbamate 

Downstream Products

• 1379653-26-5 2-(benzyloxycarbonylamino)ethyl 2-O-benzoyl-3,4-O-isopropylidene-6-O-(2-methoxy-2-propyl)-β-D-galactopyranoside 
• 1379653-29-8 C₂₃H₂₇NO₉ 
• 1379653-28-7 2-(benzyloxycarbonylamino)ethyl 2-O-benzoyl-4,6-O-di-tert-butylsilylene-β-D-galactopyranoside 
• 1379653-43-6 2-(benzyloxycarbonylamino)ethyl 2-O-benzoyl-4,6-O-di-tert-butylsilylene-3-O-levulinoyl-β-D-galactopyranoside 
• 1395062-37-9 C₂₈H₃₃NO₁₁ 
• 1379653-44-7 2-(benzyloxycarbonylamino)ethyl 2,4,6-tri-O-benzoyl-3-O-levulinoyl-β-D-galactopyranoside 
• 1379653-45-8 2-(benzyloxycarbonylamino)ethyl 2,4,6-tri-O-benzoyl-β-D-galactopyranoside 

Relevant academic research and scientific papers

Sulfonium, an Underestimated Moiety for Structural Modification, Alters the Antibacterial Profile of Vancomycin Against Multidrug-Resistant Bacteria

In the antibiotics arsenal, vancomycin is a last resort for the treatment of intractable infections. However, this situation is under threat because of the increasing appearance of vancomycin-resistant bacteria (VRB). Herein, we report a series of novel v

VANCOMYCIN DERIVATIVE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF

Provided are a class of vancomycin derivatives with a structure as shown in the general formula below and pharmaceutically acceptable salts thereof, a preparation method, a pharmaceutical composition containing the compound thereof, and the use of these compounds in preparing drugs for treating and/or preventing bacterial infection diseases, in particular drugs for treating infection diseases caused by Gram-positive bacteria.

Extra Sugar on Vancomycin: New Analogues for Combating Multidrug-Resistant Staphylococcus aureus and Vancomycin-Resistant Enterococci

Lipophilic substitution on vancomycin is an effective strategy for the development of novel vancomycin analogues against drug-resistant bacteria by enhancing bacterial cell wall interactions. However, hydrophobic structures usually lead to long elimination half-life and accumulative toxicity; therefore, hydrophilic fragments were also introduced to the lipo-vancomycin to regulate their pharmacokinetic/pharmacodynamic properties. Here, we synthesized a series of new vancomycin analogues carrying various sugar moieties on the seventh-amino acid phenyl ring and lipophilic substitutions on vancosamine with extensive structure-activity relationship analysis. The optimal analogues indicated 128-1024-fold higher activity against methicillin-susceptible S. aureus, vancomycin-intermediate resistant S. aureus (VISA), and vancomycin-resistant Enterococci (VRE) compared with that of vancomycin. In vivo pharmacokinetics studies demonstrated the effective regulation of extra sugar motifs, which shortened the half-life and addressed concerns of accumulative toxicity of lipo-vancomycin. This work presents an effective strategy for lipo-vancomycin derivative design by introducing extra sugars, which leads to better antibiotic-like properties of enhanced efficacy, optimal pharmacokinetics, and lower toxicity.

SACCHARIDE DERIVATIVE OF A TOXIC PAYLOAD AND ANTIBODY CONJUGATES THEREOF

A molecule comprising a saccharide bound via an O- glycosidic bond to a hydroxyl group of a toxic payload molecule is disclosed. An antibody-drug conjugate comprising an antibody covalently bound to a toxic payload molecule, optionally via a linker group,

Synthesis of variously sulfated biotinylated oligosaccharides from the linkage region of proteoglycans

The synthesis of a collection, as biotinylated conjugates, of various sulfoforms of the trisaccharide β-d-GlcpA-(1→3)-β-d-Galp- (1→3)-β-d-Galp, structures encountered in the linkage region of proteoglycans, is reported herein for the first time. An effici

Multivalent gold glycoclusters: High affinity molecular recognition by bacterial lectin PA-IL

Multivalent protein-carbohydrate interactions are involved in the initial stages of many fundamental biological and pathological processes through lectin-carbohydrate binding. The design of high affinity ligands is therefore necessary to study, inhibit an

Preparation of aminoethyl glycosides for glycoconjugation

The synthesis of a number of aminoethyl glycosides of cell-surface carbohydrates, which are important intermediates for glycoarray synthesis, is described. A set of protocols was developed which provide these intermediates, in a short number of steps, from commercially available starting materials.