230295-07-5

Usage

Uses

Used in Pharmaceutical Synthesis:
4-BROMO-5-PHENYL-3-(TRIFLUOROMETHYL)PYRAZOLE is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows for the development of new drugs with potential therapeutic applications.
Used in Agrochemical Synthesis:
In the agrochemical industry, 4-BROMO-5-PHENYL-3-(TRIFLUOROMETHYL)PYRAZOLE is used as a precursor for the creation of crop protection products. Its incorporation into these products can enhance their effectiveness in protecting crops from pests and diseases.
Used in Materials Science:
4-BROMO-5-PHENYL-3-(TRIFLUOROMETHYL)PYRAZOLE is utilized in the field of materials science for its potential to contribute to the development of new materials with specific properties, such as improved stability or reactivity.
Used as a Research Reagent in Biochemical Studies:
This chemical compound serves as a valuable research reagent in biochemical studies, where it can be used to investigate various biological processes and interactions, contributing to a deeper understanding of molecular mechanisms.

Upstream product

• 4027-54-7 3-(trifluoromethyl)-5-phenylpyrazole 
• 4027-54-7 3-phenyl-5-(trifluoromethyl)-1H-pyrazole 
• 326-06-7 1-Phenyl-4,4,4-trifluorobutane-1,3-dione 

Downstream Products

• 1057659-73-0 4-bromo-3-trifluoromethyl-1-methyl-5-phenylpyrazole 

Relevant academic research and scientific papers

Selective Halogenation Using an Aniline Catalyst

Electrophilic halogenation is used to produce a wide variety of halogenated compounds. Previously reported methods have been developed mainly using a reagent-based approach. Unfortunately, a suitable "catalytic" process for halogen transfer reactions has yet to be achieved. In this study, arylamines have been found to generate an N-halo arylamine intermediate, which acts as a highly reactive but selective catalytic electrophilic halogen source. A wide variety of heteroaromatic and aromatic compounds are halogenated using commercially available N-halosuccinimides, for example, NCS, NBS, and NIS, with good to excellent yields and with very high selectivity. In the case of unactivated double bonds, allylic chlorides are obtained under chlorination conditions, whereas bromocyclization occurs for polyolefin. The reactivity of the catalyst can be tuned by varying the electronic properties of the arene moiety of catalyst.

Synthesis of 1,1,1-trifluorobut-3-yn-2-ones and their reactions with N-nucleophiles

Bromination of 4-aryl-1,1,1-trifluorobut-3-yn-2-ones gives 4-aryl-3,4-dibromo-1,1,1-trifluorobut-3-en-2-ones whose reactivity towards N-nucleophiles (hydrazine and ethylenediamine) was investigated.

Synthesis of novel 1,4,5-trisubstituted 3-trifluoromethylpyrazoles via microwave-assisted Stille coupling reactions

1,5-Disubstituted 3-trifluoromethylpyrazoles were reacted with N-bromosuccinimide in DMF at room temperature or 70-80 °C for 1-2 h to afford the corresponding 4-bromo-substituted pyrazoles 2 in 95-99% yields. The microwave-assisted Stille coupling reactio