230301-11-8

Basic information

• Product Name: tert-butyl 6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-5(4H)-carboxylate
• Synonyms: tert-butyl 6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-5(4H)-carboxylate;1,4,6,7-Tetrahydro-1H-pyrazolo[4,3-C]pyridine-5-carboxylic acid tert-butyl ester;5-Boc-4,5,6,7-Tetrahydropyrazolo[4,3-c]pyridine;3-c]pyridine-5(4H)-carboxylate;7-dihydro-1H-pyrazolo[4;tert-butyl 6;1,4,6,7-Tetrahydro-pyrazolo[4,3-c]pyridine-5-carboxylic acid tert-butyl ester;tert-butyl 1H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridine-5-carboxylate
• CAS NO: 230301-11-8
• Molecular Formula: C₁₁H₁₇N₃O₂
• Molecular Weight: 223.27
• EINECS: 1312995-182-4
• Product Categories: CHIRAL CHEMICALS;Heterocycle-Pyridine series
• Mol File: 230301-11-8.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 387.979 °C at 760 mmHg
• Flash Point: 188.443 °C
• Appearance: /
• Density: 1.2g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.551
• Storage Temp.: 2-8°C
• PKA: 14.81±0.20(Predicted)
• CAS DataBase Reference: tert-butyl 6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-5(4H)-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-5(4H)-carboxylate(230301-11-8)
• EPA Substance Registry System: tert-butyl 6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-5(4H)-carboxylate(230301-11-8)

Safety Data

• Hazardous Substances Data: 230301-11-8(Hazardous Substances Data)

Usage

General Description

Tert-butyl 6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-5(4H)-carboxylate is a chemical compound with the molecular formula C16H21N3O2. It is a pyrazolopyridine derivative that is commonly used in pharmaceutical research and development. tert-butyl 6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-5(4H)-carboxylate is often utilized as a starting material for the synthesis of various pharmaceutical drugs, due to its potential pharmacological properties. Tert-butyl 6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-5(4H)-carboxylate has been studied for its potential anti-inflammatory, analgesic, and antipyretic activities, and has shown promising results in preclinical studies. Its structure and properties make it a valuable building block for the development of new therapeutically active compounds.

InChI:InChI=1/C11H17N3O2/c1-11(2,3)16-10(15)14-5-4-9-8(7-14)6-12-13-9/h6H,4-5,7H2,1-3H3,(H,12,13)

Upstream product

• 1310796-19-0 (Z)-3-((dimethylamino)methylene)-4-oxopiperidine-1-carboxylic acid tert-butyl ester 
• 1202645-17-7 3-dimethylaminomethylene-4-oxo-piperidine-1-carboxylic acid tert-butyl ester 
• 157327-41-8 t-butyl-3-[(dimethylamino)methylidene]-4-oxopiperidine-1-carboxylate 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 

Downstream Products

• 1258976-21-4 1,1-dimethylethyl 2-(5-{3-chloro-4-[(1-methylethyl)oxy]-phenyl}-1,3,4-thiadiazol-2-yl)-2,4,6,7-tetrahydro-5H-pyrazolo-[4,3-c]pyridine-5-carboxylate 
• 1258976-22-5 1,1-dimethylethyl 1-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,3,4-thiadiazol-2-yl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxylate 
• 1258976-24-7 1,1-dimethylethyl 2-(5-{3-cyano-4-[(1-methylethyl)oxy]-phenyl}-1,3,4-thiadiazol-2-yl)-2,4,6,7-tetrahydro-5H-pyrazolo-[4,3-c]pyridine-5-carboxylate 
• 1373223-68-7 4,5,6,7-tetrahydro-2-(3-pyridinyl)-2H-pyrazolo[4,3-c]pyridine 
• 100501-58-4 1-methyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine 
• 949922-59-2 tert-butyl 2-cyclopentyl-6,7-dihydro-2H-pyrazolo[4,3-c]pyridine-5(4H)-carboxylate 
• 949962-96-3 2-cyclopentyl-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridine 

Relevant articles and documents

Discovery of IDO1 inhibitors containing a decahydroquinoline, decahydro-1,6-naphthyridine, or octahydro-1H-pyrrolo[3,2-c]pyridine scaffold

A series of IDO1 inhibitors containing a decahydroquinoline, decahydro-1,6-naphthyridine, or octahydro-1H-pyrrolo[3,2-c]pyridine scaffold were identified with good cellular and human whole blood activity against IDO1. These inhibitors contain multiple chiral centers and all diastereomers were separated. The absolute stereochemistry of each isomers were not determined. Compounds 15 and 27 stood out as leads due to their good cellular as well as human whole blood IDO1 inhibition activity, low unbound clearance, and reasonable mean residence time in rat cassette PK studies.

Compound as potassium channel modulator

The invention relates to a compound as a potassium channel modulator, which is a compound of a formula (I) or a pharmaceutically acceptable salt thereof. The compound or the pharmaceutically acceptable salt thereof is effective for curing and preventing diseases and symptoms influenced by the activity of potassium ion channels.

BICYCLIC PYRAZOLE PESTICIDES

Disclosed are compounds of Formula 1, including all geometric and stereoisomers, N-oxides, and salts thereof, (1) wherein Q is (Q-1) or (Q-2); and A, R1, m, X1, X1a, X1b, X2, R2, R5, q and t are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically effective amount of a compound or a composition of the invention.