2304-83-8 Usage
Uses
Used in Research and Development:
Chrysene-1,2-quinone is used as a subject of study in the field of research and development for its potential carcinogenic properties. This helps scientists and researchers understand the mechanisms of carcinogenicity and develop strategies to mitigate the risks associated with exposure to such compounds.
Used in Environmental and Occupational Health:
Chrysene-1,2-quinone is used as a marker for assessing environmental and occupational exposure to PAHQs. By monitoring the levels of chrysene-1,2-quinone in air, water, or soil samples, researchers can evaluate the potential health risks for workers and communities exposed to these pollutants.
Used in Regulatory Compliance:
Chrysene-1,2-quinone is used as a reference compound in the development of regulations and guidelines for controlling the release of PAHQs into the environment. This helps ensure that industries and organizations adhere to safety standards and minimize the release of harmful substances.
Used in Toxicology Studies:
Chrysene-1,2-quinone is used as a test compound in toxicology studies to investigate the effects of PAHQs on human health and the environment. These studies provide valuable information on the toxicity, metabolism, and potential health risks associated with exposure to chrysene-1,2-quinone and other similar compounds.
Used in Cancer Research:
Chrysene-1,2-quinone is used as a model compound in cancer research to study the mechanisms of carcinogenesis and the development of cancer. This helps researchers identify potential targets for therapeutic intervention and develop new strategies for cancer prevention and treatment.
Check Digit Verification of cas no
The CAS Registry Mumber 2304-83-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,3,0 and 4 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 2304-83:
(6*2)+(5*3)+(4*0)+(3*4)+(2*8)+(1*3)=58
58 % 10 = 8
So 2304-83-8 is a valid CAS Registry Number.
InChI:InChI=1/C18H10O2/c19-17-10-9-15-14-6-5-11-3-1-2-4-12(11)13(14)7-8-16(15)18(17)20/h1-10H
2304-83-8Relevant academic research and scientific papers
Synthesis of the Dihydrodiol and Diol Epoxide Metabolites of Chrysene and 5-Methylchrysene
Harvey, Ronald G.,Pataki, John,Lee, Hongmee
, p. 1407 - 1412 (2007/10/02)
Carcinogenic polycyclic aromatic hydrocarbons are known to undergo enzymatic activation to diol epoxide metabolites bearing an epoxide ring in a bay molecular region.Introduction of a methyl group into a nonbenzo bay region position generally enhances carcinogenic activity.We now report efficient syntheses of the diasteromeric anti and syn bay region diol epoxide derivatives of both chrysene and 5-methylchrysene (5-MC) in both bay regions.The anti- and syn-1,2-diol-3,4-epoxide derivatives of 5-MC (1b and 2b) are the first examples of synthetic diol epoxides with a methyl group in the same bay region as the epoxide ring.NMR analysis indicates that these diol epoxide derivatives and the related dihydrodiols, with the exception of 2b and the syn-7,8-diol-9,10-epoxide of 5-methylchrysene (2c), exist preferentially in the diequational conformation in solution; 2b and 2c show a slight predominance of the diaxial conformer.All the synthetic diol epoxides were sufficiently stable to conduct biological experiments on tumorigenicity and DNA binding on mouse skin; the results confirm that 1b is the major active carcinogenic form of 5-methylchrysene which binds covalently to DNA in vivo.
