2305-27-3

Usage

Physical Appearance

White to off-white powder

Common Uses

Building block in the synthesis of pharmaceuticals and organic compounds
Chelating agent
Intermediate in dye and pigment production

Importance of cisIsomer

Significant in pharmaceutical synthesis due to specific stereochemical properties

Other Applications

Studied for potential use in organic electronic devices
Component in polymer materials

Upstream product

• 108-31-6 maleic anhydride 
• 91-13-4 α,α'-dibromo-o-xylene 

Relevant academic research and scientific papers

Metallic Nickel Assisted Room-Temperature Generation and Diels-Alder Chemistry of o-Xylylene Intermediates

Highly reactive metallic nickel, prepared by the lithium metal reduction of nickel iodide using naphthalene as an electron carrier, was found to induce 1,4-dehalogenation of α,α'-dihalo-o-xylene derivatives at room temperature.The reaction proceeds in the presence of a variety of electron-deficient olefins, giving Diels-Alder cycloadducts in moderate to good yields presumably via the highly reactive intermediate o-xylylene 2. 1,3-Dibromoindan and 1,4-dibromo-1,2,3,4-tetrahydronaphthalene also react in the presence of electron-deficient olefins to give bridged cycloadducts in moderate yields.Methoxy as well as electron-deficient substituents such as bromide and nitrile groups on the aromatic ring of the starting dibromide were shown to be compatible with the reaction conditions yielding substituted cycloadducts in good yields.