2305-65-9

Basic information

• Product Name: 6-nitro-4-oxo-1,4-dihydroquinoline-3-carbonitrile
• Synonyms: 4-Hydroxy-6-nitrochinolin-3-carbonitril; 4-hydroxy-6-nitroquinoline-3-carbonitrile; 6-Nitro-4-oxo-1,4-dihydrochinolin-3-carbonitril
• CAS NO: 2305-65-9
• Molecular Formula: C₁₀H₅N₃O₃
• Molecular Weight: 215.165
• Mol File: 2305-65-9.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 394.683°C at 760 mmHg
• Flash Point: 192.498°C
• Density: 1.534g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.674
• CAS DataBase Reference: 6-nitro-4-oxo-1,4-dihydroquinoline-3-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 6-nitro-4-oxo-1,4-dihydroquinoline-3-carbonitrile(2305-65-9)
• EPA Substance Registry System: 6-nitro-4-oxo-1,4-dihydroquinoline-3-carbonitrile(2305-65-9)

Safety Data

• Hazardous Substances Data: 2305-65-9(Hazardous Substances Data)

Upstream product

• 57338-20-2 2-Cyano-3-(4-nitro-phenylamino)-acrylic acid ethyl ester 
• 100-01-6 4-nitro-aniline 
• 2458-24-4 2-cyano-3-(4-nitro-phenylamino)-acrylic acid ethyl ester 
• 57338-24-6 (E)-ethyl 2-cyano-3-((4-nitrophenyl)amino)acrylate 

Downstream Products

• 214484-15-8 N-[4-[(3-bromophenyl)amino]-3-cyano-6-quinolinyl]-2-propenamide 
• 214485-09-3 4-[(3-chloro-4-fluorophenyl)amino]-6-nitro-quinoline-3-carbonitrile 
• 214485-08-2 6-Amino-4-[(3-chloro-4-fluorophenyl)amino]-quinoline-3-carbonitrile 
• 214484-09-0 4-[(3-bromophenyl)amino]-6-nitro-quinoline-3-carbonitrile 
• 214484-11-4 6-amino-4-[(3-bromophenyl)-amino]-3-quinolinecarbonitrile 
• 214485-06-0 N-{4-[(3-chloro-4-fluorophenyl)amino]-3-cyano-6-quinolinyl}-4-morpholino-2-butenamide 
• 214485-37-7 N-{4-[(3-bromo-4-fluorophenyl)amino]-3-cyano-6-quinolinyl}-4-morpholino-2-butenamide 
• 214485-16-2 N-{4-[(3-chloro-4-thiophenoxyphenyl)amino]-3-cyano-6-quinolinyl}-2-butynamide 
• 214485-05-9 N-{4-[(3-chloro-4-fluorophenyl)amino]-3-cyano-6-quinolinyl}-4-diethylamino-2-butenamide 
• 214486-84-7 N-{4-[(3-chloro-4-thiophenoxyphenyl)amino]-3-cyano-6-quinolinyl}-2-propenamide 
• 214484-72-7 4-diethylamino-but-2-enoic acid [4-(3-bromophenylamino)-3-cyano-quinolin-6-yl]-amide 
• 214485-35-5 N-{4-[(3-bromo-4-fluorophenyl)amino]-3-cyano-6-quinolinyl}-4-dimethylamino-2-butenamide 
• 214484-73-8 4-methylamino-but-2-enoic acid [4-(3-bromophenylamino)-3-cyano-quinolin-6-yl]-amide 
• 214484-71-6 4-dimethylamino-but-2-enoic acid [4-(3-bromophenylamino)-3-cyano-quinolin-6-yl]-amide 

Relevant articles and documents

NITROGENOUS HETEROCYCLIC COMPOUND, PREPARATION METHOD, INTERMEDIATE, COMPOSITION, AND APPLICATION

A nitrogenous heterocyclic compound, a preparation method, an intermediate, a composition, and an application. The present invention provides a nitrogenous heterocyclic compound as represented by formula I, pharmaceutically acceptable salts thereof, enantiomers thereof, diastereoisomers thereof, tautomers thereof, solvates thereof, metabolites thereof, or prodrugs thereof. The compound has high inhibitory activity against ErbB2 tyrosine kinase, has good inhibitory activity against human breast cancer cells BT-474, human gastric cancer cells NCI-N87 and the like with high expression of ErbB2, and in addition has relatively weak inhibitory activity against EGFR kinase, that is, the compound is an EGFR/ErbB2 double target inhibitor that attenuates EGFR kinase inhibitory activity or a small-molecule inhibitor having selectivity for an ErbB2 target. (I)

Substituted 3-cyanoquinolines as protein tyrosine kinases inhibitors

This invention provides compounds of formula 1 wherein R1, G1, G2, R4, Z, X and n are defined herein, or a pharmaceutically acceptable salt thereof, which are useful as antineoplastic agents and in the treatment of polycystic kidney disease.

3-Cyanoquinoline inhibitors of Tpl2 kinase and methods of making and using the same

The present invention provides compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, m and n are defined as