23056-40-8

Basic information

• Product Name: 2-Chloro-5-methyl-3-nitropyridine
• Synonyms: 6-CHLORO-5-NITRO-3-PICOLINE;2-CHLORO-5-METHYL-3-NITROPYRIDINE;2-CHLORO-3-NITRO-5-METHYLPYRIDINE;2-CHLORO-3-NITRO-5-PICOLINE;2-Chloro-3,5-dimethyl-4-methoxypyridine;2-Chloro-5-methyl-3-nitropyridine 97%;2-CHLORO-3-NITRO-5-PICOLINE (2-CHLORO-5-METHYL-3-NITROPYRIDINE);2-Chloro-3-nitro-5-picoline,98%
• CAS NO: 23056-40-8
• Molecular Formula: C₆H₅ClN₂O₂
• Molecular Weight: 172.57
• EINECS: -0
• Product Categories: blocks;NitroCompounds;Pyridines;Pyridine;Chloropyridines;Halopyridines;pyridine series;Building Blocks;C5 to C6;C6;Chemical Synthesis;Halogenated Heterocycles;Heterocyclic Building Blocks
• Mol File: 23056-40-8.mol
• Article Data: 10

Chemical Properties

• Melting Point: 46-50 °C
• Boiling Point: 290.8 °C at 760 mmHg
• Flash Point: 129.7 °C
• Appearance: Beige powder
• Density: 1.406 g/cm³
• Vapor Pressure: 0.00353mmHg at 25°C
• Refractive Index: 1.575
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -2.20±0.10(Predicted)
• Sensitive: Hygroscopic
• BRN: 138198
• CAS DataBase Reference: 2-Chloro-5-methyl-3-nitropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-5-methyl-3-nitropyridine(23056-40-8)
• EPA Substance Registry System: 2-Chloro-5-methyl-3-nitropyridine(23056-40-8)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 36/37/38-21/22-41-37/38-22
• Safety Statements: 36/37/39-26-36-39
• RIDADR: 2811
• WGK Germany: 3
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 23056-40-8(Hazardous Substances Data)

Usage

Chemical Properties

Beige powder

InChI:InChI=1/C6H5ClN2O2/c1-4-2-5(9(10)11)6(7)8-3-4/h2-3H,1H3

Upstream product

• 7464-14-4 2-hydroxy-5-methyl-3-nitropyridine 
• 1003-68-5 5-methyl-pyridin-2-ol 
• 1603-41-4 (5-methyl-pyridin-2-yl)amine 
• 7464-14-4 5-methyl-3-nitropyridin-2(1H)-one 

Downstream Products

• 21901-25-7 3-nitro-5-methyl-2-hydrazine-pyridine 
• 5337-84-8 6-methyl-8-nitro-tetrazolopyridin 
• 137320-30-0 5-methyl-3,3'-dinitro-2,2'-bipyridine 
• 2164-62-7 5,5'-dimethyl-3,3'-dinitro-2,2'-bipyridine 
• 1024-94-8 3,3’-dinitro-2,2’-bipyridine 
• 33252-62-9 2-methoxy-5-methyl-3-nitropyridine 
• 106690-38-4 2-(N-methylamino)-5-methyl-3-nitropyridine 
• 123846-68-4 (5-Methyl-3-nitro-pyridin-2-yl)-acetonitrile 
• 23945-84-8 6-chloro-5-nitro-nicotinoyl chloride 
• 7477-10-3 6-chloro-5-nitronicotinic acid 
• 1443995-60-5 C₂₁H₂₆N₄O₅ 
• 1443995-66-1 C₂₁H₂₇N₅O₃ 
• 1443995-27-4 C₁₆H₁₈N₄O₃ 
• 1408054-37-4 C₁₆H₁₉N₅O 

Relevant articles and documents

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PROTEASOME ACTIVITY ENHANCING COMPOUNDS

The present invention is directed to compounds having the Formula (I), (II), (III), (IV), and (V), compositions thereof, the methods of synthesis of the compouds of interest, and to methods for the treatment of a condition associated with a dysfunction in proteostasis, such as cancer, inflammatory conditions, neurodegeneration, metabolic conditions, comprising administering an effective amount of a compound of the invention.

Synthesis and evaluation of 8-amino-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one derivatives as glycogen synthase kinase-3 (GSK-3) inhibitors

New potent glycogen synthase kinase-3 (GSK-3) inhibitors, 8-amino-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one derivatives, were designed by modeling, synthesized and evaluated in vitro. Compound 17c showed good potency in enzyme and cell-based assays (IC50 = 111 nM, EC50 = 1.78 μM). Moreover, it has demonstrated desirable water solubility, PK profile, and moderate brain penetration.