23056-47-5

Basic information

• Product Name: 2-Bromo-5-nitro-4-picoline
• Synonyms: 2-BROMO-4-METHYL-5-NITROPYRIDINE;2-BROMO-5-NITRO-4-METHYL PYRIDINE;2-BROMO-5-NITRO-4-PICOLINE;2-BROMO-5-NITRO-4-PICOLINE (2-BROMO-4-METHYL-5-NITROPYRIDINE);2-bromo-4-methyl-;5-broMo-4-Methyl-2-nitropyridine;2-BroMo-4-Methyl-5-nitropyridin;2-BroMo-5-nitro-4-picolin...
• CAS NO: 23056-47-5
• Molecular Formula: C₆H₅BrN₂O₂
• Molecular Weight: 217.02
• Product Categories: compounds of pyridine;Pyridine;Pyridines;Boronic Acid;Heterocycle-Pyridine series
• Mol File: 23056-47-5.mol
• Article Data: 7

Chemical Properties

• Melting Point: 64-66°C
• Boiling Point: 294.2 °C at 760 mmHg
• Flash Point: 131.8 °C
• Appearance: /
• Density: 1.709 g/cm³
• Vapor Pressure: 0.00288mmHg at 25°C
• Refractive Index: 1.599
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• PKA: -2.59±0.18(Predicted)
• CAS DataBase Reference: 2-Bromo-5-nitro-4-picoline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-5-nitro-4-picoline(23056-47-5)
• EPA Substance Registry System: 2-Bromo-5-nitro-4-picoline(23056-47-5)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 23056-47-5(Hazardous Substances Data)

Usage

Uses

2-Bromo-4-methyl-5-nitropyridine acts as a reagent for the synthetic preparation of azaindole hydroxamic acid as potent HIV-1 integrase inhibitors, discovery of 3,5-substituted 6-azaindazoles as potent pan-Pim inhibitors.

InChI:InChI=1/C6H5BrN2O2/c1-4-2-6(7)8-3-5(4)9(10)11/h2-3H,1H3

Upstream product

• 21901-40-6 2-amino-5-nitro-4-picoline 
• 695-34-1 2-Amino-4-methylpyridine 
• 21901-41-7 2-hydroxy-4-methyl-5-nitropyridine 
• 21295-51-2 phosphoryl(III) bromide 

Downstream Products

• 267875-30-9 4-methyl-5-nitropyridine-2-carbonitrile 
• 944317-54-8 4-methyl-6-(trifluoromethyl)pyridine-3-amine 
• 800401-87-0 5-cyano-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid ethyl ester 
• 800401-88-1 5-cyano-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid 
• 800401-70-1 ethyl 5-bromo-1H-pyrrolo[2,3-c]pyridine-2-carboxylate 
• 800401-71-2 5-bromo-1 H-pyrrolo[2,3-c]pyridine-2-carboxylic acid 

Relevant articles and documents

PLASMA KALLIKREIN INHIBITORS AND USES THEREOF

The present invention provides compounds and compositions thereof which are useful as inhibitors of plasma kallikrein and which exhibit desirable characteristics for the same.

Azaindole hydroxamic acids are potent HIV-1 integrase inhibitors

HIV-1 integrase (IN) is one of three enzymes encoded by the HIV genome and is essential for viral replication. Recently, HIV-1 IN inhibitors have emerged as a new promising class of therapeutics. Herein, we report the discovery of azaindole carboxylic aci

PYRROLOPYRIDINE-2-CARBOXYLIC ACID AMIDE INHIBITORS OF GLYCOGEN PHOSHORYLASE

Compounds represented by Formula (I): or pharmaceutically acceptable salts thereof, are inhibitors of glycogen phosphorylase and are useful in the prophylactic or therapeutic treatment of diabetes, hyperglycemia, hypercholesterolemia, hyperinsulinemia, hyperlipidemia, hypertension, atherosclerosis or tissue ischemia e.g. myocardial ischemia, and as cardioprotectants.