230618-42-5Relevant articles and documents
Pyrrolidine-containing polypyridines: New ligands for improved visible light absorption by ruthenium complexes
Martineau, David,Beley, Marc,Gros, Philippe C.
, p. 566 - 571 (2006)
A range of new electron-releasing pyrrolidine-containing bipyridines and terpyridines has been prepared via selective metalation-cross-coupling sequences. The obtained ligands have been involved in microwave-assisted ruthenium complexation leading to homoleptic complexes in high yield. The electron-donor effect of the pyrrolidine nucleus led to a notable improvement of visible light absorption and strong changes in the electrochemical behavior, opening new opportunities for the design of photovoltaic devices.
SPIROPIPERIDINE DERIVATIVES
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Page/Page column 160, (2010/11/27)
The invention provides compounds of formula (I): wherein the dotted line represents an optional covalent bond between X and Y, and X, Y, Z, m, R2, R3, R4, R5, R6, R7, R8, R9, a and b have the meanings given in the specification, and pharmaceutically acceptable salts and solvates thereof. The compounds are delta opioid receptor agonists and have a number of therapeutic applications, particularly in the treatment of pain.
Studies on the mechanism of action of 2-formyl-4-pyrrolidinopyridine: Isolation and characterization of a reactive intermediate
Sammakia, Tarek,Hurley, T. Brian
, p. 4652 - 4664 (2007/10/03)
This paper describes the mechanism of action of 2-formyl-4- pyrrolidinopyridine (FPP, 1a) which is a catalyst for the hydroxyl-directed methanolysis of α-hydroxy esters. This species was initially designed to act as a nucleophilic catalyst; however, we have ruled out a nucleophilic mechanism by examining the activity of 6-substituted-FPP derivatives. These compounds are more hindered in the vicinity of the pyridine nitrogen than FPP itself but are also more active catalysts. Furthermore, the presence of p- nitrophenol, a mild acid, was found to accelerate the catalytic reaction. These results are inconsistent with a nucleophilic catalysis mechanism. We provide evidence that the reaction instead proceeds via dioxolanone intermediate 10. Dioxolanone 10 can be obtained by treating either the p- nitrophenyl ester or the pentafluorophenyl ester of glycolic acid with FPP in chloroform in the absence of methanol. It has been isolated, characterized, and shown to be kinetically competent when subjected to the conditions of the catalytic reaction.