23071-44-5

Upstream product

• 327-46-8 2-fluoro-butyric acid ethyl ester 
• 877-35-0 2-bromo-1-phenylbutan-1-one 
• 914801-66-4 N-(2-fluoro-1-phenylbutylidene)cyclohexylamine 
• 77821-53-5 butyrophenone iminate 
• 4385-98-2 ethylbenzoylacetate 
• 84839-88-3 trimethyl{(1-phenylbut-1-en-1-yl)oxy}silane 

Downstream Products

• 76650-11-8 2-bromo-2-fluoro-1-phenylbutan-1-one 
• 76650-16-3 1,1-Diethoxy-1-phenyl-butan-2-one 
• 66255-88-7 1,1-Dimethoxy-1-phenyl-butan-2-one 
• 1355165-74-0 2-fluoro-1,2-diphenylbutan-1-one 
• 1588767-25-2 (S)-2-fluoro-1,2-diphenylbutan-1-one 
• 1588767-94-5 (S)-2-fluoro-2-(4-isopropylphenyl)-1-phenylbutan-1-one 
• 1588768-04-0 (S)-2-fluoro-2-(3-isopropylphenyl)-1-phenylbutan-1-one 

Relevant academic research and scientific papers

A Carbene Strategy for Progressive (Deutero)Hydrodefluorination of Fluoroalkyl Ketones

Hydrodefluorination is one of the most promising chemical strategies to degrade perfluorochemicals into partially fluorinated compounds. However, controlled progressive hydrodefluorination remains a significant challenge, owing to the decrease in the stre

Bench-Stable Electrophilic Fluorinating Reagents for Highly Selective Mono- and Difluorination of Silyl Enol Ethers

Efficient methods for the synthesis of fluorinated compounds have been intensively studied, recently. Development of practical fluorinating reagents is indispensable for this purpose. Herein, bench-stable electrophilic fluorinating reagents were synthesized as N-fluorobenzenesulfonimide (NFSI) substitutes. Reagents obtained by replacing one of the NFSI sulfonyl groups with an acyl group led to the highly selective monofluorination of silyl enol ethers with suppression of undesired overreaction, that is, difluorination. On the other hand, reagents bearing electron-withdrawing substituents at NFSI benzenesulfonyl groups efficiently facilitated the difluorination of silyl enol ethers under base-free conditions. Thus, both mono- and difluorinated target materials were prepared from the same substrate.

Decarboxylative fluorination of β-Ketoacids with N-fluorobenzenesulfonimide (NFSI) for the synthesis of α-fluoroketones: Substrate scope and mechanistic investigation

Cesium carbonate (Cs2CO3)-mediated decarboxylative fluorination of β-ketoacids using NFSI in the MeCN/H2O mixed solvent system affords α-fluoroketones with a broad scope. Both electron-rich and electron-deficient α-non-substituted β-ketoacids are amenable to this protocol. The mechanistic study indicates that the reaction proceeds through electrophilic fluorination followed by decarboxylation, which is different from the decarboxylative fluorination of normal carboxylic acids.

Direct electrophilic α-fluorination of imines: Efficient synthesis of mono-and difluoroimines

(Chemical Equation Presented) A mild and efficient procedure to synthesize α-fluoro- and α,α-difluoroimines was developed. Various N-alkylimines derived from acetophenones were successfully monofluorinated using NFSI (N-fluorobenzenesulfonimide) in a mixture of CH3CN and DMF at 0°C. Alternatively, the same procedure without DMF gave rise to difluorinated imines when performed at room temperature. The obtained α- and α,α-difluorinated imines were subsequently reduced to give the corresponding β-fluoro- and β,β-difluoroamines in good yield.

REGIOSPECIFIC SYNTHESIS OF α-KETOACETALS BY REARRANGEMENT OF α-BROMO-α-FLUOROKETONES

α-Ketoacetals, derived from alkylaryl-α-diones and with acetalized benzoyl moiety, were synthesized by alkoxide induced rearrangement of α-bromo-α-fluoroalkylarylketones.