23073-50-9Relevant articles and documents
A cyclized O-phenylenediamine-based compound of the method for preparing benzimidazole
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Paragraph 0038-0040, (2017/01/19)
The invention belongs to the field of fine chemistry and relates to an improved synthesis method of a benzimidazole compound and a related chemical technology. The synthesis method is characterized by comprising the step of with o-phenylenediamine and 1, 3-dicarbonyl compound as raw materials, synthesizing the benzimidazole compound under the catalysis of protonic acid. The invention mainly provides a novel synthesis method of the benzimidazole compound. The method has the advantages of mild reaction conditions, simple step, easily-obtained raw materials, good functional group compatibility and the like. Benzimidazole is an important biological active group and is widely applied in the field of pharmacy, and therefore, the preparation method has relatively high use value as well as social and economic benefits.
Convenient synthesis of benzothiazoles and benzimidazoles through bronsted acid catalyzed cyclization of 2-amino thiophenols/anilines with β-diketones
Mayo, Muhammad Shareef,Yu, Xiaoqiang,Zhou, Xiaoyu,Feng, Xiujuan,Yamamoto, Yoshinori,Bao, Ming
supporting information, p. 764 - 767 (2014/03/21)
Bronsted acid catalyzed cyclization reactions of 2-amino thiophenols/anilines with β-diketones under oxidant-, metal-, and radiation-free conditions are described. Various 2-substituted benzothiazoles/benzimidazoles are obtained in satisfactory to excellent yields. Different groups such as methyl, chloro, nitro, and methoxy linked on benzene rings were tolerated under the optimized reaction conditions.