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23077-42-1

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23077-42-1 Usage

Description

1H-INDOLE-3-CARBOXYLIC ACID,4-FLUORO-, also known as 4-Fluoro-1H-indole-3-carboxylic Acid, is a chemical compound that belongs to the class of organic compounds known as fluoroindoles. It is an aromatic heteropolycyclic compound with an indole ring fluorinated at position 4 and carboxylated at position 3. The presence of the fluorine atom in the molecular structure alters the chemical and physical properties, often enhancing the biological activity of these compounds. 1H-INDOLE-3-CARBOXYLIC ACID,4-FLUOROis frequently used in research and development activities, particularly in the field of medicinal chemistry where it serves as a building block for more complex chemical structures.

Uses

Used in Medicinal Chemistry:
1H-INDOLE-3-CARBOXYLIC ACID,4-FLUOROis used as a building block for the synthesis of more complex chemical structures in medicinal chemistry. The presence of the fluorine atom in its molecular structure can enhance the biological activity of the resulting compounds, making them more effective in various therapeutic applications.
Used in Research and Development:
1H-INDOLE-3-CARBOXYLIC ACID,4-FLUOROis used as a research compound in the development of new drugs and pharmaceuticals. Its unique molecular structure and properties make it a valuable tool for studying the interactions between molecules and their potential applications in medicine.
Used in Drug Design:
1H-INDOLE-3-CARBOXYLIC ACID,4-FLUOROis used as a starting material in the design of new drugs, particularly in the field of medicinal chemistry. The fluorine atom in its structure can influence the compound's reactivity, stability, and interaction with biological targets, making it a useful component in the development of novel therapeutic agents.

Check Digit Verification of cas no

The CAS Registry Mumber 23077-42-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,3,0,7 and 7 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 23077-42:
(7*2)+(6*3)+(5*0)+(4*7)+(3*7)+(2*4)+(1*2)=91
91 % 10 = 1
So 23077-42-1 is a valid CAS Registry Number.

23077-42-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-fluoro-1H-indole-3-carboxylic acid

1.2 Other means of identification

Product number -
Other names RD-0113

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:23077-42-1 SDS

23077-42-1Downstream Products

23077-42-1Relevant articles and documents

PYRIMIDINE COMPOUND, PREPARATION METHOD THEREOF AND MEDICAL USE THEREOF

-

Paragraph 0359; 0489; 0491, (2021/04/10)

The present invention discloses a pyrimidine compound, a preparation method thereof and a medical use thereof. Specifically, the present invention discloses a pyrimidine compound represented by formula (I), pharmaceutically acceptable salts thereof, a preparation method thereof, and a use thereof as a cyclin-dependent kinase 9 (CDK9) inhibitor, particularly for the treatment of cancer. The definition of each group in formula (I) is the same as that in the specification.

Amphiphilic Indole Derivatives as Antimycobacterial Agents: Structure-Activity Relationships and Membrane Targeting Properties

Yang, Tianming,Moreira, Wilfried,Nyantakyi, Samuel Agyei,Chen, Huan,Aziz, Dinah binte,Go, Mei-Lin,Dick, Thomas

, p. 2745 - 2763 (2017/04/21)

Antibacterials that disrupt cell membrane function have the potential to eradicate “persister” organisms and delay the emergence of resistance. Here we report the antimycobacterial activities of 4-fluoro and 6-methoxyindoles bearing a cationic amphiphilic motif represented by a lipophilic n-octyl side chain at position 1 and a positively charged azepanyl or 1,4-dioxa-8-azaspiro[4.5]decane moiety at position 3. These analogues exhibited balanced profiles of potency (Mycobacterium bovis BCG, M tuberculosis H37Rv), selective activity, solubility, and metabolic stability. Bacteriological mechanism of action investigations on a representative analogue revealed cell membrane permeabilization and depolarization in M bovis BCG. These membrane-related changes preceded cell death indicating that the loss in membrane integrity was not an epiphenomenon. Bactericidal activity was observed against both growing and nongrowing mycobacterial cultures. The analogue also upregulated cell envelope stress-inducible promoters piniBAC and pclgR, implicating the involvement of envelope-related targets in its mode of action.

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