23095-16-1

Basic information

• Product Name: Benzenesulfonyl chloride, 2-broMo-4-Methoxy-
• Synonyms: Benzenesulfonyl chloride, 2-broMo-4-Methoxy-
• CAS NO: 23095-16-1
• Molecular Formula: C₇H₆BrClO₃S
• Molecular Weight: 285.54274
• Mol File: 23095-16-1.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzenesulfonyl chloride, 2-broMo-4-Methoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenesulfonyl chloride, 2-broMo-4-Methoxy-(23095-16-1)
• EPA Substance Registry System: Benzenesulfonyl chloride, 2-broMo-4-Methoxy-(23095-16-1)

Safety Data

• Hazardous Substances Data: 23095-16-1(Hazardous Substances Data)

Upstream product

• 2398-37-0 3-methoxyphenyl bromide 

Downstream Products

• 1038988-09-8 1-(2-bromo-4-methoxybenzenesulfonyl)-4-(4-methylpiperazin-1-ylmethyl)-1H-indole 
• 1301768-16-0 2-bromo-4-methoxy-N-(2-methylallyl)benzenesulfonamide 
• 1301768-03-5 tert-butyl N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(4R)-7-methoxy-4-methyl-1,1-dioxo-1,3,4,5-tetrahydro-2H-1λ6,2-benzothiazepin-2-yl]propyl}carbamate 
• 1309607-04-2 C₂₁H₂₈N₂O₄S 
• 1309607-08-6 C₂₁H₂₈N₂O₄S 
• 1301768-24-0 C₂₆H₃₆N₂O₆S 
• 1301768-04-6 tert-butyl N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(4S)-7-methoxy-4-methyl-1,1-dioxo-1,3,4,5-tetrahydro-2H-1λ6,2-benzothiazepin-2-yl]propyl}carbamate 
• 153624-71-6 N-(3,4-dimethyl-5-isoxazolyl)-N-((methoxyethoxy)methyl)-2-bromo-4-methoxybenzenesulfonamide 
• 153624-70-5 N-(3,4-dimethyl-5-isoxazolyl)-2-bromo-4-methoxybenzenesulfonamide 
• 23095-17-2 2-Brom-4-methoxy-benzolsulfonsaeurehydrazid 

Relevant articles and documents

Ammonium formate-based one-pot reductive Heck reactions for the construction of cyclic sulfonamides

A modified method is reported for the conversion of unsaturated sulfonamides into their cyclic saturated counterparts. This method utilises a single palladium catalyst for an intramolecular Heck reaction and subsequent transfer hydrogenation, which is ach

Biphenylsulfonamide endothelin antagonists: Structure-activity relationships of a series of mono- and disubstituted analogues and pharmacology of the orally active endothelin antagonist 2'-amino-N-(3,4- dimethyl-5-isoxazolyl)-4'-(2-methylpropyl)[1,1'-biphenyl]-2-sulfonamide (BMS- 187308)

Substitution at the ortho position of N-(3,4-dimethyl-5-isoxazolyl) benzenesulfonamide led to the identification of the biphenylsulfonamides as a novel series of endothelin-A (ETA) selective antagonists. Appropriate substitutions on the pendant phenyl ring led to improved binding as well as functional activity. A hydrophobic group such as isobutyl or isopropoxyl was found to be optimal at the 4'-position. Introduction of an amino group at the 2'-position also led to improved analogues. Combination of the optimal 4'- isobutyl substituent with the 2'-amino function afforded an analogue (20, BMS-187308) with improved ET(A) binding affinity and functional activity. Compound 20 also has good oral activity in inhibiting the pressor effect caused by an ET-1 infusion in rats. Doses of 10 and 30 μmol/kg iv 20 attenuated the pressor responses due to the administration of exogenous ET-1 to conscious monkeys, indicating that the compound inhibits the in vivo activity of endothelin-1 in nonhuman primates.