23095-84-3

Basic information

• Product Name: (5alpha,6alpha)-3-hydroxy-17-methyl-7,8-didehydro-4,5-epoxymorphinan-6-yl hydrogen sulfate
• Synonyms: Morphinan-3,6-diol, 7,8-didehydro-4,5-epoxy-17-methyl- (5α,6α)-, 6-(hydrogen sulfate)
• CAS NO: 23095-84-3
• Molecular Formula: C₁₇H₁₉NO₆S
• Molecular Weight: 365.4009
• Mol File: 23095-84-3.mol
• Article Data: 2

Chemical Properties

• Melting Point: >256 °C (decomp)
• Density: 1.63g/cm³
• Refractive Index: 1.725
• PKA: -4.00±0.18(Predicted)
• CAS DataBase Reference: (5alpha,6alpha)-3-hydroxy-17-methyl-7,8-didehydro-4,5-epoxymorphinan-6-yl hydrogen sulfate(CAS DataBase Reference)
• NIST Chemistry Reference: (5alpha,6alpha)-3-hydroxy-17-methyl-7,8-didehydro-4,5-epoxymorphinan-6-yl hydrogen sulfate(23095-84-3)
• EPA Substance Registry System: (5alpha,6alpha)-3-hydroxy-17-methyl-7,8-didehydro-4,5-epoxymorphinan-6-yl hydrogen sulfate(23095-84-3)

Safety Data

• Hazardous Substances Data: 23095-84-3(Hazardous Substances Data)

Usage

Uses

Morphine 6-sulfate is used in the compositions, methods and kits for safe inhaled delivery of targeted opioids for treatment of pain and addiction.

Upstream product

• 561-27-3 Diamorphine 
• 2784-73-8 6-monoacetylmorphine 
• 57-27-2 MORPHIN 
• 1268252-29-4 C₁₉H₂₁NO₇S 

Downstream Products

• 7664-93-9 sulfuric acid 
• 57-27-2 MORPHIN 
• 509-60-4 dihydromorphine 

Relevant articles and documents

Sulfate esters of morphine derivatives: Synthesis and characterization

Sixteen 3-O- and 6-O-sulfate esters of morphine, codeine and some of their N-methyl quaternary derivatives were synthesized by means of sulfation with pyridine-SO3 complex and sulfuric acid/N,N′- dicyclohexylcarbodiimide. Complete 1H- and 13C-NMR assignments are given for each of the synthesized compounds based on one- and two-dimensional homo- and heteronuclear measurements. Comparative analysis of chiral properties by circular dichroism and optical rotatory dispersion revealed characteristic differences in the spectra due to changes in charge, polarity and intramolecular association by strong hydrogen bonds in aqueous solution. The synthesized sulfate esters are prospective peripheral analgesics lacking central side effects and are also useful as reference substances for various analytical studies involving sulfate ester metabolites.