23111-45-7

Usage

InChI:InChI=1/C11H12N2O2S/c1-14-7-3-4-8(10(5-7)15-2)9-6-16-11(12)13-9/h3-6H,1-2H3,(H2,12,13)

Upstream product

• 17356-08-0 thiourea 
• 829-20-9 2',4'-dimethoxyacetophenone 
• 60965-26-6 2-Bromo-2',4'-dimethoxyacetophenone 
• 4783-90-8 2-chloro-1-(2,4-dimethoxyphenyl)ethanone 

Downstream Products

• 23111-21-9 2-(4-chloro-phenoxy)-N-[4-(2,4-dimethoxy-phenyl)-thiazol-2-yl]-acetamide 
• 23111-50-4 N-[4-(2,4-dimethoxy-phenyl)-thiazol-2-yl]-propionamide 
• 20375-58-0 N-[4-(2,4-dimethoxy-phenyl)-thiazol-2-yl]-benzamide 
• 23111-48-0 N-[4-(2,4-dimethoxy-phenyl)-thiazol-2-yl]-acetamide 
• 81529-86-4 2-Ethoxyethyl N-[4-(2,4-dimethoxyphenyl)-thiazol-2-yl]-oxamate 

Relevant academic research and scientific papers

IMPROVED MODULATORS OF HEC1 ACTIVITY AND METHODS THEREFOR

Compounds, compositions, and methods for modulation of Hec1/Nek2 interaction are provided. Such compounds disrupt Nek2/Hec1 binding and may be useful as chemotherapeutic agents for neoplastic diseases

I2/CuO-catalyzed tandem cyclization strategy for one-pot synthesis of substituted 2-aminothiozole from easily available aromatic ketones/α,β-unsaturated ketones and thiourea

A concise and efficient one-pot process from easily available methyl ketones/unsaturated methyl ketones and thiourea was developed for the synthesis of 2-aminothiazoles under the media of I2/CuO. The method can highly stereoselectivity obtain the E-isomers of 4-ethenyl-2-aminothiazoles (5a-f). All these target molecules were characterized by NMR, HRMS and IR spectra. Furthermore, the target compounds 3c and 5b were further determined by X-ray crystallographic analysis.

Modulators Of HEC1 Activity And Methods Therefor

Compounds, compositions, and methods for modulation of Hec1/Nek2 interaction are provided. Especially preferred compounds disrupt Nek2/Hec1 binding and are therefore useful as chemotherapeutic agent for neoplastic diseases.