23117-65-9

Upstream product

• 62001-29-0 N-phenyl-1H-benzotriazolyl-1-methanamine 
• 21300-30-1 lithium 1-cyclohexenolate 
• 50-00-0 formaldehyd 
• 108-94-1 cyclohexanone 
• 62-53-3 aniline 
• 103-01-5 N-Phenylglycine 

Downstream Products

• 89410-13-9 2-chloro-3-phenyl-5,6-tetrahydromethylenetetrahydro-1,3,2-oxazaphosphorin-2-oxide 
• 1284229-75-9 5-phenyl-5,6,6a,7,8,9-hexahydrophenanthridine 
• 1284229-92-0 (E)-4-methyl-N'-{2-[(phenylamino)methyl]cyclohexylidene}benzenesulfonohydrazide 
• 1610556-48-3 C₁₄H₁₉N 
• 1610556-53-0 C₁₅H₁₈ClNO 
• 92195-98-7 2-Anilinomethyl-1-cyclohexanol 

Relevant academic research and scientific papers

Palladium-Catalyzed Phosphoryl-Carbamoylation of Alkenes: Construction of Nonbenzylic C(sp3)?P(O)R2 Bonds via C(sp3)?Pd(II)?P(O)R2 Reductive Elimination

We report the first example of palladium-catalyzed phosphoryl-carbamoylation of alkene-tethered carbamoyl chlorides with P(O)H compounds. Both H-phosphinates and secondary phosphine oxides are compatible with this reaction. DPE-Phos was used as ligand to facilitate nonbenzylic C(sp3)?P bonds formations via C(sp3)?Pd(II)?P reductive elimination. By using this protocol, a range of phosphorylated oxindoles and lactams were obtained in moderate to good yields. (Figure presented.).

Synthesis of substituted γ-lactam via Pd(0)-catalyzed cyclization of alkene-tethered carbamoyl chloride

Pd(0)-catalyzed carboiodonation of but-3-enylcarbamic chloride has been developed with NaI as additive, which provides a ready access to substituted γ-lactam bearing an alkyl iodide group. This reaction features alkyl iodide reductive elimination as a key step in catalytic cycle, indicating the crucial role of additive NaI.

Amphiphilic methyleneamino synthon through organic dye catalyzed- decarboxylative aminoalkylation

The utilization of a photo-induced synthon generated from N-phenyl glycine by an organic dye and visible light irradiation is disclosed. The intermediate could be coupled with either a radical or a nucleophile in a simple operation to afford several natural product-like compounds.

Tosylhydrazide-promoted palladium-catalyzed reaction of β-aminoketones with o-dihaloarenes: Combining organocatalysis and transition-metal catalysis

(Chemical Equation Presented) Working in tandem: Mannich adducts obtained by organocatalyzed processes are readily transformed into phenanthridine and quinoline derivatives by a Pd-catalyzed cascade reaction involving tosylhydrazide (TsNHNH2)-promoted cross-coupling followed by intramolecular amination (see scheme; MW=microwave). The enantioselectivity achieved in the organocatalytic reaction is maintained throughout the process.

Benzotriazole-assisted synthesis of novel mannich bases from ketones and diverse aldehydes

A wide variety of β-amino ketones are prepared in moderate to good yields by the reaction of the lithium enolates of cyclohexanone, acetophenone, α-tetralone and camphor with the readily available adducts from an aldehyde or ketone, an amine and benzotriazole. Some diastereoselectivity is observed when the benzotriazole adduct is derived from benzaldehyde.