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Product FOB Price Min.Order Supply Ability Supplier
Top Quality USP Standard API Lapatinib
Cas No: 231277-92-2
USD $ 1.0-1.0 / Gram 1 Gram 100 Kilogram/Day Theta biotechnology CO.,LTD Contact Supplier
Sell Top Quality USP Standard API Lapatinib
Cas No: 231277-92-2
USD $ 1.0-2.0 / Gram 10 Gram 1000 Metric Ton/Month Hubei Jusheng Technology Co., Ltd., Contact Supplier
Cas No: 231277-92-2
USD $ 1.0-1.0 / Kilogram 1 Kilogram 100 Kilogram/Month HANWAYS CHEMPHARM CO.,LIMITED Contact Supplier
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No Data No Data Metric Ton/Day DALIAN BAIJIA IMPORT AND EXPORT CO., LTD Contact Supplier
Lapatinib Manufacturer CAS No.231277-92-2
Cas No: 231277-92-2
No Data 10 Gram 1000 Kilogram/Month Henan Surface Industry Co Ltd Contact Supplier
Lapatinib 231277-92-2
Cas No: 231277-92-2
No Data 1 Gram 1000 Gram/Month Taizhou Crene Biotechnology co.ltd Contact Supplier
Cas No: 231277-92-2
No Data No Data No Data Jinan Jianfeng Chemical Co., Ltd Contact Supplier
Lapatinib Manufacturer/High quality/Best price/In stock
Cas No: 231277-92-2
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Hangzhou Dayangchem Co., Ltd. Contact Supplier
Lapatinib CAS NO.231277-92-2
Cas No: 231277-92-2
USD $ 2.0-2.0 / Gram 100 Gram 100 Metric Ton/Month Hebei yanxi chemical co.,LTD. Contact Supplier
CAS:231277-92-2 Lapatinib factory sales
Cas No: 231277-92-2
No Data 1 Kilogram 100 Kilogram/Week Kono Chem Co.,Ltd Contact Supplier

231277-92-2 Usage


An antineoplastic agent used in breast cancer research

Mechanisms of Action

Lapatinib is a tyrosine kinase inhibitor which can effectively inhibit the tyrosine kinase activity of human epidermal growth factor receptors 1 and 2 (ErbB1, ErbB2). It can uniquely act in a variety of ways, ensuring that breast cancer cells cannot receive growth signals. It inhibits intracellular EGFR (ErbB-1) and HER2 (ErbB-2) ATP sites, preventing tumor cell phosphorylation and activation, blocking down-regulation signals through the homogeneity and heterogeneity of EGFR (ErbB-1) and HER2 (ErbB-1) dimerization.

Indications and Usage

Lapatinib is a drug targeting breast cancer developed by British GlaxoSmithKline Co.
Human ErbB receptors belong to the type I tyrosine kinase (TK) receptor family, including ErbB1 (EGFR), ErbB2 (HER2), ErbB3 (HER3), and ErbB4 (HER4). The ErbB-1 (EGFR) and ErbB-2 (HER-2) receptors are often overexpressed or otherwise altered in cancer patients. Human epidermal growth factor receptor 2 (ErbB-2, HER-2) is known to be a human oncogene closely related with breast cancer. Its high expression in breast cancer often predicts lymph node metastasis and poor tumor differentiation, with poor prognosis. HER-2 is one of the target molecules for breast cancer-specific therapy. Lapatinib can act simultaneously on both Her-1 Her-2. The biological effects of this method inhibiting the proliferation and growth of tumor cells are much larger than only acting on one target. The combination of Lapatinib with Capecitabine is used to treat patients with advanced or metastatic breast cancer with overexpression of human epidermal receptor2, already treated with anthracyclines, paclitaxel, and trastuzumab. Clinical trials have shown that Lapatinib also effectively treats HER2-type cancer patients with Herceptin resistance.


antineoplastic, tyrosine kinase inhibitor


Lapatinib, used in the form of Lapatinib Ditosylate, is a potent EGFR and ErbB2 inhibitor with IC50 of 10.8 and 9.2 nM, respectively.


Lapatinib Ditosylate (GW572016, GW2016, Tykerb, Tyverb) is a potent EGFR and ErbB2 inhibitor with IC50 of 10.8 and 9.2 nM, respectively.



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017


1.1 GHS Product identifier

Product name lapatinib

1.2 Other means of identification

Product number -
Other names Tykerb

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

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