231287-89-1

Basic information

• Product Name: 6-Bromo-4-nitropyridine-2-carboxylic acid
• Synonyms: 6-Bromo-4-nitropyridine-2-carboxylic acid;6-Bromo-4-nitropicolinic acid
• CAS NO: 231287-89-1
• Molecular Formula: C₆H₃BrN₂O₄
• Molecular Weight: 247.00302
• Mol File: 231287-89-1.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 420.9±45.0 °C(Predicted)
• Appearance: /
• Density: 2.004±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 2.49±0.10(Predicted)
• CAS DataBase Reference: 6-Bromo-4-nitropyridine-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Bromo-4-nitropyridine-2-carboxylic acid(231287-89-1)
• EPA Substance Registry System: 6-Bromo-4-nitropyridine-2-carboxylic acid(231287-89-1)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26
• Hazardous Substances Data: 231287-89-1(Hazardous Substances Data)

Usage

Chemical Properties

Off-white solid

Upstream product

• 97944-46-2 2-bromo-6-methyl-4-nitro-pyridine 

Downstream Products

• 521917-52-2 (4-amino-6-bromo-pyridin-2-yl)-methanol 

Relevant articles and documents

Discovery of Small-Molecule Cyclic GMP-AMP Synthase Inhibitors

Cyclic guanosine monophosphate-adenosine monophosphate (GMP-AMP) (cGAS), a cytosolic DNA sensor, plays an important role in the type I interferon response. DNA from either invading microbes or self-origin triggers the enzymatic activity of cGAS. Aberrant activation of cGAS is associated with various autoimmune disorders. Only one selective probe exists for inhibiting cGAS in cells, while others are limited by their poor cellular activity or specificity, which underscores the urgency for discovering new cGAS inhibitors. Here, we describe the development of new small-molecule human cGAS (hcGAS) inhibitors (80 compounds synthesized) with high binding affinity in vitro and cellular activity. Our studies show CU-32 and CU-76 selectively inhibit the DNA pathway in human cells but have no effect on the RIG-I-MAVS or Toll-like receptor pathways. CU-32 and CU-76 represent a new class of hcGAS inhibitors with activity in cells and provide a new chemical scaffold for designing probes to study cGAS function and development of autoimmune therapeutics.

2-(3,4-Dihydro-1H-isoquinolin-2yl)-pyridines as a novel class of NR1/2B subtype selective NMDA receptor antagonists

Recently, we disclosed 4-aminoquinolines as structurally novel NR1/2B subtype selective NMDA receptor antagonists. We would now like to report our findings on structurally related pyridine analogues. The SAR developed in this series resulted in the discovery of high affinity antagonists which are selective (vs α1 and M1 receptors) and active in vivo.

Conjugated aromatic compounds with a pyridine substituent

The present invention relates to compounds of formulae The compounds of the present invention are NMDA (N-methyl-D-aspartate)-receptor subtype blockers and are used in the treatment of diseases related to this receptor.