23130-89-4Relevant academic research and scientific papers
A mild procedure for the Lewis acid-catalyzed ring-opening of activated cyclopropanes with amine nucleophiles
Lifchits, Olga,Charette, Andre B.
supporting information; experimental part, p. 2809 - 2812 (2009/05/27)
(Chemical Equation Presented) The Lewis acid-catalyzed ring-opening of methyl 1-nitrocyclopropanecarboxylates with amine nucleophiles is described. The reaction proceeds at room temperature and with complete preservation of the enantiomeric purity from th
Synthesis and activity of a new class of dual acting norepinephrine and serotonin reuptake inhibitors: 3-(1H-indol-1-yl)-3-arylpropan-1-amines
Mahaney, Paige E.,Vu, An T.,McComas, Casey C.,Zhang, Puwen,Nogle, Lisa M.,Watts, William L.,Sarkahian, Ani,Leventhal, Liza,Sullivan, Nicole R.,Uveges, Albert J.,Trybulski, Eugene J.
, p. 8455 - 8466 (2008/02/04)
Compounds with a combination of norepinephrine and serotonin reuptake inhibition have been approved in the US and Europe for a number of indications, including major depressive disorder and pain disorders such as diabetic neuropathy and fibromyalgia. Efforts to design selective norepinephrine reuptake inhibitors based on SAR from the aryloxypropanamine series of monoamine reuptake inhibitors have led to the identification of a potent new class of dual acting norepinephrine and serotonin reuptake inhibitors, namely the 3-(1H-indol-1-yl)-3-arylpropan-1-amines.
