23145-16-6

Basic information

• Product Name: 5-BROMO-1-BENZOFURAN-2-CARBALDEHYDE
• Synonyms: 5-BROMOBENZO[B]FURAN-2-CARBALDEHYDE;5-BROMO-1-BENZOFURAN-2-CARBALDEHYDE;5-BROMO-1-BENZOFURAN-2-CARBOXALDEHYDE;5-Bromo-1-benzofurane-2-carbaldehyde;5-Bromo-1-benzofuran-2-carboxaldehyde 97%;5-Bromobenzo[b]furan-2-carboxaldehyde;5-Bromobenzo[b]furan-2-carboxaldehyde 97%;5-broMobenzofuran-2-carbaldehyde
• CAS NO: 23145-16-6
• Molecular Formula: C₉H₅BrO₂
• Molecular Weight: 225.04
• Mol File: 23145-16-6.mol
• Article Data: 7

Chemical Properties

• Melting Point: 129 °C
• Boiling Point: 312.447 °C at 760 mmHg
• Flash Point: 142.763 °C
• Appearance: white to light yellow crystal powder
• Density: 1.677 g/cm³
• Vapor Pressure: 0.000529mmHg at 25°C
• Refractive Index: 1.682
• CAS DataBase Reference: 5-BROMO-1-BENZOFURAN-2-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-1-BENZOFURAN-2-CARBALDEHYDE(23145-16-6)
• EPA Substance Registry System: 5-BROMO-1-BENZOFURAN-2-CARBALDEHYDE(23145-16-6)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-36-22
• Safety Statements: 22-26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 23145-16-6(Hazardous Substances Data)

Usage

Chemical Properties

white to light yellow crystal powde

Uses

5-Bromobenzo[b]furan-2-carbaldehyde is used in the synthesis of biscationic, trypanocidal 1-benzofuran compounds.

InChI:InChI=1/C9H5BrO2/c10-7-1-2-9-6(3-7)4-8(5-11)12-9/h1-5H

Upstream product

• 26028-36-4 5-bromo-2-benzofurancarboxylic acid methyl ester 
• 38220-77-8 5-bromo-2-(hydroxymethyl)-1-benzofuran 
• 10242-11-2 5-bromobenzo[b]furan-2-carboxylic acid 
• 106-41-2 4-bromo-phenol 
• 1761-61-1 5-bromosalicyclaldehyde 
• 7252-83-7 1-bromo-2,2-dimethoxyethane 
• 197577-35-8 5-bromo-2-hydroxymethyl-2,3-dihydrobenzo[b]furan 
• 23145-26-8 5-bromo-2-[2,2-(dimethoxy)ethoxy]benzaldehyde 

Downstream Products

• 38220-77-8 5-bromo-2-(hydroxymethyl)-1-benzofuran 
• 1391766-43-0 C₁₀H₄BrF₃O₂ 

Relevant articles and documents

A study of the Claisen-Eschenmoser reaction for hydroxymethylbenzofurans and-indoles

N,N-Dimethylacetamide dimethyl acetal reacted with 5(7)-substituted 2-(hydroxy-methyl)benzofurans to give N,N-dimethyl-2-(2-methylbenzofuran-3-yl) acetamides. Analogous reactions with 3-(hydroxymethyl)indole and 1-hydroxy-6-methyl-1,2,3,4-tetrahydro-carbazole afforded N,N-dimethyl-3-(3- indolyl)propionamide and N, N-dimethyl-2-(6-methyl-1,2,3,4-tetrahydrocarbazol-1- yl)acetamide, respectively.

PD-1/PD-L1 INHIBITORS

Compounds according to formula (I), methods of using said compounds singly or in combination with additional agents and compositions of said compounds for the treatment of cancer are disclosed.

GLUCOSYLCERAMIDE SYNTHASE INHIBITORS FOR THE TREATMENT OF DISEASES

Described herein are compounds of Formula I, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or conditions associated with the enzyme glucosylceramide synthase (GCS).