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23145-88-2

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23145-88-2 Usage

Chemical Properties

Clear yellow liquid

Uses

1-(4-Chlorobenzyl)piperazine is an inhibitor of [3H]5-HT uptake into rat brain synaptosomes. Also inhibits the acute effects of MDMA.

Check Digit Verification of cas no

The CAS Registry Mumber 23145-88-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,3,1,4 and 5 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 23145-88:
(7*2)+(6*3)+(5*1)+(4*4)+(3*5)+(2*8)+(1*8)=92
92 % 10 = 2
So 23145-88-2 is a valid CAS Registry Number.
InChI:InChI=1/C11H15ClN2/c12-11-3-1-2-10(8-11)9-14-6-4-13-5-7-14/h1-3,8,13H,4-7,9H2

23145-88-2 Well-known Company Product Price

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  • Alfa Aesar

  • (H55337)  1-(4-Chlorobenzyl)piperazine, 98%   

  • 23145-88-2

  • 1g

  • 277.0CNY

  • Detail
  • Alfa Aesar

  • (H55337)  1-(4-Chlorobenzyl)piperazine, 98%   

  • 23145-88-2

  • 5g

  • 956.0CNY

  • Detail
  • Alfa Aesar

  • (H55337)  1-(4-Chlorobenzyl)piperazine, 98%   

  • 23145-88-2

  • 25g

  • 3787.0CNY

  • Detail
  • Aldrich

  • (650218)  1-(4-Chlorobenzyl)piperazine  98%

  • 23145-88-2

  • 650218-1G

  • 482.04CNY

  • Detail
  • Aldrich

  • (650218)  1-(4-Chlorobenzyl)piperazine  98%

  • 23145-88-2

  • 650218-5G

  • 1,590.03CNY

  • Detail

23145-88-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-(4-CHLOROBENZYL)PIPERAZINE

1.2 Other means of identification

Product number -
Other names 1-(4-Chlorobenzyl)piperazine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:23145-88-2 SDS

23145-88-2Relevant articles and documents

Synthesis and evaluation of paeonol derivatives as potential multifunctional agents for the treatment of alzheimer's disease

Zhou, An,Wu, Hongfei,Pan, Jian,Wang, Xuncui,Li, Jiaming,Wu, Zeyu,Hui, Ailing

, p. 1304 - 1318 (2015)

(A.H.); Alzheimer's disease (AD) is a progressive neurodegenerative brain disorder characterized by memory loss, language impairment, personality changes and intellectual decline. Taking into account the key pathological features of AD, such as low levels of acetylcholine, beta-amyloid (Aβ) aggregation, oxidative stress and dyshomeostasis of biometals, a new series of paeonol derivatives 5a-5d merging three different functions, i.e., antioxidant, anti-acetylcholinesterase (AChE) activity, metal chelating agents for AD treatment have been synthesized and characterized. Biological assays revealed that compared with paeonol (309.7 μM), 5a-5d had a lower DPPH IC50 value (142.8-191.6 μM). 5a-5d could significantly inhibit hydrogen peroxide-induced neuronal PC12 cell death assessed by MTT assay in the concentration range of 5-40 μM. AChE activity was effectively inhibited by 5a-5d, with IC50 values in the range of 0.61-7.04 μM. 5a-5d also exhibited good metal-chelating ability. All the above results suggested that paeonol derivatives may be promising multifunctional agents for AD treatment.

Further SAR studies on natural template based neuroprotective molecules for the treatment of Alzheimer's disease

Singh, Yash Pal,Shankar, Gauri,Jahan, Shagufta,Singh, Gourav,Kumar, Navneet,Barik, Atanu,Upadhyay, Prabhat,Singh, Lovejit,Kamble, Kajal,Singh, Gireesh Kumar,Tiwari, Sanjay,Garg, Prabha,Gupta, Sarika,Modi, Gyan

, (2021/09/04)

In our earlier paper, we described ferulic acid (FA) template based novel series of multifunctional cholinesterase (ChE) inhibitors for the management of AD. This report has further extended the structure–activity relationship (SAR) studies of this series of molecules in a calibrated manner to improve upon the ChEs inhibition and antioxidant property to identify the novel potent multifunctional molecules. To investigate the effect of replacement of phenylpiperazine ring with benzylpiperazine, increase in the linker length between FA and substituted phenyl ring, and replacement of indole moiety with tryptamine on this molecular template, three series of novel molecules were developed. All synthesized compounds were tested for their acetyl and butyryl cholinestrases (AChE and BChE) inhibitory properties. Enzyme inhibition and PAS binding studies identified compound 13b as a lead molecule with potent inhibitor property towards AChE/BChE (AChE IC50 = 0.96 ± 0.14 μM, BChE IC50 = 1.23 ± 0.23 μM) compared to earlier identified lead molecule EJMC-G (AChE IC50 = 5.74 ± 0.13 μM, BChE IC50 = 14.05 ± 0.10 μM, respectively). Molecular docking and dynamics studies revealed that 13b fits well into the active sites of AChE and BChE, forming stable and strong interactions with key residues Trp86, Ser125, Glu202, Trp 286, Phe295, Tyr 337 in AChE, and with Trp 82, Gly115, Tyr128, and Ser287 in BChE. The compound, 13b was found to be three times more potent antioxidant in a DPPH assay (IC50 = 20.25 ± 0.26 μM) over the earlier identified EJMC-B (IC50 = 61.98 ± 0.30 μM) and it also was able to chelate iron. Co-treatment of 13b with H2O2, significantly attenuated and reversed H2O2-induced toxicity in the SH-SY5Y cells. The parallel artificial membrane permeability assay-blood brain barrier (PAMPA-BBB) revealed that 13b could cross BBB efficiently. Finally, the in-vivo efficacy of 13b at dose of 10 mg/kg in scopolamine AD model has been demonstrated. The present study strongly suggests that the naturally inspired multifunctional molecule 13b may behave as a potential novel therapeutic agent for AD management.

Design, synthesis, and evaluation of genipin derivatives for the treatment of Alzheimer's Disease

Huang, Weijun,Wang, Yujun,Li, Jiaming,Zhang, Yanchun,Ma, Xiaodong,Zhu, Panhu,Zhang, Yang

, p. 110 - 122 (2018/12/11)

Twenty-two novel genipin derivatives have been designed, synthesized, and evaluated for their inhibitory activity against acetylcholinesterase (AChE). As a result, compound 13a bearing ligustrazine moiety displayed the most potent AChE inhibitory activity in this series with IC50 value of 218?nm. Besides, MTT assay was performed to investigate the neuroprotection of these compounds against PC12 cells injured by Amyloid β-protein 1–42 (Aβ1–42). Among them, 8a showed higher inhibition rate (%Inhibition?=?22.29) than the positive reference Donepezil (%Inhibition?=?17.65).

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