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23145-91-7

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23145-91-7 Usage

Chemical Properties

Colorless liquid

Check Digit Verification of cas no

The CAS Registry Mumber 23145-91-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,3,1,4 and 5 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 23145-91:
(7*2)+(6*3)+(5*1)+(4*4)+(3*5)+(2*9)+(1*1)=87
87 % 10 = 7
So 23145-91-7 is a valid CAS Registry Number.
InChI:InChI=1/C11H15ClN2/c12-11-3-1-2-10(8-11)9-14-6-4-13-5-7-14/h1-3,8,13H,4-7,9H2/p+2

23145-91-7 Well-known Company Product Price

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  • (Code)Product description
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  • Detail
  • Alfa Aesar

  • (H55409)  1-(3-Chlorobenzyl)piperazine, 98%   

  • 23145-91-7

  • 1g

  • 183.0CNY

  • Detail
  • Alfa Aesar

  • (H55409)  1-(3-Chlorobenzyl)piperazine, 98%   

  • 23145-91-7

  • 5g

  • 403.0CNY

  • Detail
  • Alfa Aesar

  • (H55409)  1-(3-Chlorobenzyl)piperazine, 98%   

  • 23145-91-7

  • 25g

  • 1495.0CNY

  • Detail
  • Aldrich

  • (652814)  1-(3-Chlorobenzyl)piperazine  98%

  • 23145-91-7

  • 652814-1G

  • 236.34CNY

  • Detail
  • Aldrich

  • (652814)  1-(3-Chlorobenzyl)piperazine  98%

  • 23145-91-7

  • 652814-10G

  • 1,247.22CNY

  • Detail
  • Aldrich

  • (650269)  1-(3-Chlorobenzyl)piperazine  98%

  • 23145-91-7

  • 650269-1G

  • 286.65CNY

  • Detail

23145-91-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-[(3-chlorophenyl)methyl]piperazine

1.2 Other means of identification

Product number -
Other names 4-(3-chlorophenyl)methylpiperazine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:23145-91-7 SDS

23145-91-7Relevant articles and documents

Design, synthesis and SAR of antitubercular benzylpiperazine ureas

Satish, Sohal,Chitral, Rohan,Kori, Amitkumar,Sharma, Basantkumar,Puttur, Jayashree,Khan, Afreen A.,Desle, Deepali,Raikuvar, Kavita,Korkegian, Aaron,Martis, Elvis A. F.,Iyer, Krishna R.,Coutinho, Evans C.,Parish, Tanya,Nandan, Santosh

, (2021/01/04)

Abstract: N-furfuryl piperazine ureas disclosed by scientists at GSK Tres Cantos were chosen as antimycobacterial hits from a phenotypic whole-cell screen. Bioisosteric replacement of the furan ring in the GSK Tres Cantos molecules with a phenyl ring led to molecule (I) with an MIC of 1?μM against Mtb H37Rv, low cellular toxicity (HepG2 IC50 ~ 80?μM), good DMPK properties and specificity for Mtb. With the aim of delineating the SAR associated with (I), fifty-five analogs were synthesized and screened against Mtb. The SAR suggests that the piperazine ring, benzyl urea and piperonyl moieties are essential signatures of this series. Active compounds in this series are metabolically stable, have low cellular toxicity and are valuable leads for optimization. Molecular docking suggests these molecules occupy the Q0 site of QcrB like Q203. Graphic Abstract: Bioisosteric replacement of N-furfuryl piperazine-1-carboxamides yielded molecule (I) a novel lead with satisfactory PD, metabolism, and toxicity profiles.[Figure not available: see fulltext.]

New potent antifungal triazole alcohols containing N-benzylpiperazine carbodithioate moiety: Synthesis, in vitro evaluation and in silico study

Mahmoudi, Yaser,Badali, Hamid,Hashemi, Seyedeh Mahdieh,Ansari, Mahsa,Fakhim, Hamed,Fallah, Marjan,Shokrzadeh, Mohammad,Emami, Saeed

, (2019/06/24)

A number of 1H-1,2,4-triazole alcohols containing N-(halobenzyl)piperazine carbodithioate moiety have been designed and synthesized as potent antifungal agents. In vitro bioassays against different Candida species including C. albicans, C. glabrata, C. parapsilosis, C. krusei, and C. tropicalis revealed that the N-(4-chlorobenzyl) derivative (6b) with MIC values of 0.063–0.5 μg/mL had the best profile of activity, being 4–32 times more potent than fluconazole. Docking simulation studies confirmed the better fitting of compound 6b in the active site of lanosterol 14α-demethylase (CYP51) enzyme, the main target of azole antifungals. Particularly, the potential of compound 6b against fluconazole-resistant isolates along with its minimal toxicity against human erythrocytes and HepG2 cells make this prototype compound as a good lead for discovery of potent and safe antifungal agents.

A newly synthesized sinapic acid derivative inhibits endothelial activation in vitro and in vivos

Zeng, Xiaoyun,Zheng, Jinhong,Fu, Chenglai,Su, Hang,Sun, Xiaoli,Zhang, Xuesi,Hou, Yingjian,Zhu, Yi

, p. 1099 - 1108 (2013/06/27)

Inhibition of oxidative stress and inflammation in vascular endothelial cells (ECs) may represent a new therapeutic strategy against endothelial activation. Sinapic acid (SA), a phenylpropanoid compound, is found in natural herbs and high-bran cereals and has moderate antioxidant activity. We aimed to develop new SA agents with the properties of antioxidation and blocking EC activation for possible therapy of cardiovascular disease. We designed and synthesized 10 SA derivatives according to their chemical structures. Preliminary screening of the compounds involved scavenging hydroxyl radicals and 2,2-diphenyl-1- picrylhydrazyl (DPPH×), croton oil-induced ear edema in mice, and analysis of the mRNA expression of adhesion molecules in ECs. 1- Acetyl-sinapic acyl-4-(39-chlorine-)benzylpiperazine (SA9) had the strongest antioxidant and anti-inflammatory activities both in vitro and in vivo. Thus, the effect of SA9 was further studied. SA9 inhibited tumor necrosis factor a-induced upregulation of adhesion molecules in ECs at both mRNA and protein levels, as well as the consequent monocyte adhesion to ECs. In vivo, result of face-toface immunostaining showed that SA9 reduced lipopolysaccharideinduced expression of intercellular adhesion molecule-1 in mouse aortic intima. To study the molecular mechanism, results from luciferase assay, nuclear translocation of NF-kB, and Western blot indicated that the mechanism of the anti-inflammatory effects of SA9 might be suppression of intracellular generation of ROS and inhibition of NF-kB activation in ECs. SA9 is a prototype of a novel class of antioxidant with anti-inflammatory effects in ECs. It may represent a new therapeutic approach for preventing endothelial activation in cardiovascular disorders.

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