23152-45-6Relevant academic research and scientific papers
Anticonvulsant 4-Aryl Semicarbazides and Thioureas
Nagarajan, K.,David, J.,Rajappa, S.,Talwalker, S.
, p. 934 - 939 (2007/10/02)
Among a series of anticonvulsant 1-aryl semicarbazides, 1-(3,5-bistrifluoromethyl)phenylsemicarbazide, C 3884-Go (11) and its 4-methyl derivative, C 3165-Go (12) showed good activity of long duration in the electroshock test in mice and rats.Quantitative structure activity analysis indicates that ? and ? values are respectively important for the aromatic and side chain substituents respectively.N-Acetyl-N'-(3,5-bistrifluoromethyl)phenyl hydrazine (20) is highly anticonvulsant but causes ataxia. 4-Aryl thiosemicarbazides show weak to moderate activity.Among N-(3,5-bistrifluoromethyl)phenyl thiocarbamoyl derivatives, the product 33 from N-benzyl piperazine is potent in the electroshock test.Compounds 11 and 12 have been compared with standards such as phenytoin, phenurone and carbamazepine.
Antiimplantation Agents: Part I - 1-Arylthiosemicarbazides
Nagarajan, K.,Talwalker, P.K.,Kulkarni, C.L.,Venkateswarlu, A.,Prabhu, S.S.,Nayak, G.V.
, p. 1243 - 1257 (2007/10/02)
Several 1-arylthiosemicarbazides, 2-arylhydrazinothiazolines and 2-arylhydrazinodihydrothiazines have been examined for their antiimplantation activity in rats.Among the active compounds, 4-methyl-1-(3,5-bistrifluoromethylphenyl)thiosemicarbazide (3, C 2696-Go) and the corresponding 4,4-dimethyl (47), ethyl (4), n-butyl (5) and allyl (6) derivatives completely inhibit implantation at doses 10, 3, 20, 20 and 30 mg/kg respectively.The 3,4-dichlorophenyl analogue (32) is effective at a dose of 30 mg/kg. 2-(3,5-Bistrifluoromethylphenyl)hydrazinothiazoline (51) and the corresponding dihydrothiazine (63) show a weaker activity.The biological profile of C 2696-Go has been investigated in detail.It appears to prevent implantation by its antiuterotropic activity and ability to inhibit desiduoma formation.
