23153-12-0

Basic information

• Product Name: 3-Chloro-4-methylsulfonylaniline
• Synonyms: 3-CHLORO-4-METHYLSULFONYLANILINE;3-Chloro-4-(methylsulphonyl)aniline;3-Chloro-4-(methylsulfonyl)phenylamine;3-Chloro-4-methanesulfonyl-aniline
• CAS NO: 23153-12-0
• Molecular Formula: C₇H₈ClNO₂S
• Molecular Weight: 205.66
• Product Categories: Amines and Anilines;Boron, Nitrile, Thio,& TM-Cpds;API intermediates
• Mol File: 23153-12-0.mol
• Article Data: 2

Chemical Properties

• Melting Point: 170-171
• Boiling Point: 423.015 °C at 760 mmHg
• Flash Point: 209.632 °C
• Appearance: /
• Density: 1.414g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.584
• Storage Temp.: 2-8°C(protect from light)
• PKA: 0.29±0.10(Predicted)
• CAS DataBase Reference: 3-Chloro-4-methylsulfonylaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Chloro-4-methylsulfonylaniline(23153-12-0)
• EPA Substance Registry System: 3-Chloro-4-methylsulfonylaniline(23153-12-0)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 23153-12-0(Hazardous Substances Data)

Usage

Description

3-Chloro-4-methylsulfonylaniline, with the molecular formula C7H8ClNO2S, is an organic compound characterized by the presence of a chlorine atom attached to the fourth carbon and a methylsulfonyl group attached to the amino group of aniline. This versatile building block is known for its wide range of industrial applications, particularly in the synthesis of pharmaceuticals, agrochemicals, and dyes.

Uses

Used in Pharmaceutical Industry:
3-Chloro-4-methylsulfonylaniline is used as a key intermediate in the synthesis of various pharmaceuticals. Its unique structure allows for the development of new drugs with improved therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical industry, 3-Chloro-4-methylsulfonylaniline serves as an essential precursor for the production of various agrochemicals, contributing to the development of effective pest control solutions.
Used in Dye Industry:
3-Chloro-4-methylsulfonylaniline is used as a precursor for the production of 3-chloro-4-aminobenzenesulfonic acid, which is utilized in the manufacture of azo and anthraquinone dyes. Its presence in these dyes enhances their color properties and stability.
Used in Chemical Synthesis:
The chlorine and methylsulfonyl groups in 3-Chloro-4-methylsulfonylaniline make it a valuable building block for the synthesis of a wide range of organic compounds, expanding its applications across various industries.

InChI:InChI=1/C7H8ClNO2S/c1-12(10,11)7-3-2-5(9)4-6(7)8/h2-4H,9H2,1H3

Upstream product

• 77146-55-5 2-chloro-1-(methylsulfanyl)-4-nitrobenzene 
• 350-30-1 3-chloro-4-fluoronitrobenzene 
• 91842-77-2 2-chloro-4-nitrophenyl methyl sulfone 

Relevant articles and documents

1-PHENYLPYRROLE COMPOUNDS

The present invention comprises a compound for the prevention and/or treatment of cardiovascular diseases, nephropathy, fibrosis, primary aldosteronism or edema. The compound is of the following general formula (I): wherein R1 represents a C1 -C3 alkyl group; R2 represents a hydroxy -C1 -C4 alkyl group and the like; R3 represents a halogeno group, a halogeno-C1 -C3 alkyl group and the like; R4 represents a hydrogen atom, a halogeno group and the like,- R5 represents a sulfamoyl group or a C1-C3 alkylsulf onyl group; R6 represents a hydrogen atom, a halogeno group and the like] or an N-oxide, atropisomer of the foregoing, or pharmaceutically acceptable salt of the foregoing.