231617-15-5Relevant articles and documents
Synthesis of 3-substituted isocoumarins via a cascade intramolecular Ullmann-type coupling-rearrangement process
Ge, Zhi-Yuan,Fei, Xiang-Dong,Tang, Ting,Zhu, Yong-Ming,Shen, Jing-Kang
experimental part, p. 5736 - 5743 (2012/08/07)
A simple and highly efficient strategy for the synthesis of 3-substituted isocoumarins through a copper(I)-catalyzed reaction of 1-(2-halophenyl)-1,3- diones has been developed. The procedure is based on a cascade copper-catalyzed intramolecular Ullmann-type C-arylation and rearrangement process. This methodology is tolerant of a wide range of substrates and applicable to library synthesis.